DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE
- Product Name
- DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE
- CAS No.
- 99974-66-0
- Chemical Name
- DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE
- Synonyms
- DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE;1,1-Cyclobutanedicarboxylic acid, 3-hydroxy-, 1,1-diethyl ester
- CBNumber
- CB92465426
- Molecular Formula
- C10H16O5
- Formula Weight
- 216.23
- MOL File
- 99974-66-0.mol
DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE Property
- Boiling point:
- 120-122 °C(Press: 3 Torr)
- Density
- 1.1108 g/cm3(Temp: 25 °C)
- storage temp.
- 2-8°C
- pka
- 14.23±0.40(Predicted)
- Appearance
- Colorless to off-white Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 092903
- Product name
- Diethyl3-hydroxycyclobutane-1,1-dicarboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- W9889
- Product name
- Diethyl3-hydroxycyclobutane-1,1-dicarboxylate
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FD141623
- Product name
- Diethyl 3-hydroxycyclobutane-1,1-dicarboxylate
- Packaging
- 500mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- FD141623
- Product name
- Diethyl 3-hydroxycyclobutane-1,1-dicarboxylate
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FD141623
- Product name
- Diethyl 3-hydroxycyclobutane-1,1-dicarboxylate
- Packaging
- 1g
- Price
- $331.25
- Updated
- 2021/12/16
DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE Chemical Properties,Usage,Production
Synthesis
54166-15-3
99974-66-0
The general procedure for the synthesis of 3-hydroxy-1,1-cyclobutanedicarboxylic acid-1,1-diethyl ester from 3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid is as follows: 3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid-diethyl ester (2 g) was dissolved in ethanol (EtOH, 100 ml), and 10% palladium/carbon (Pd/C, 400 mg, 20% equiv) was added. The reaction suspension was subjected to hydrogenation at room temperature overnight. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure to afford the product 3-hydroxy-1,1-cyclobutanedicarboxylic acid-1,1-diethyl ester (1.3 g, 91.5% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) with the following chemical shifts: δ 2.44-2.49 (m, 2H), 2.85-2.90 (m, 2H), 4.35-4.37 (m, 1H), 4.21 (q, J=7.2 Hz, 4H), 1.26 (t, J=10.8 Hz, 6H).
References
[1] Research on Chemical Intermediates, 2015, vol. 41, # 11, p. 8725 - 8733
[2] Synthesis (Germany), 2012, vol. 44, # 13, p. 2091 - 2101
[3] Patent: WO2009/8913, 2009, A2. Location in patent: Page/Page column 60
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 7, p. 2151 - 2155
[5] Patent: WO2010/70615, 2010, A1. Location in patent: Page/Page column 28; 29
DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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