5-FLUORO-2-NITROBENZAMIDE
- Product Name
- 5-FLUORO-2-NITROBENZAMIDE
- CAS No.
- 77206-97-4
- Chemical Name
- 5-FLUORO-2-NITROBENZAMIDE
- Synonyms
- 5-FLUORO-2-NITROBENZAMIDE;Benzamide, 5-fluoro-2-nitro-;5-fluoro-2-nitrobenzamide5-fluoro-2-nitrobenzamide
- CBNumber
- CB92466443
- Molecular Formula
- C7H5FN2O3
- Formula Weight
- 184.12
- MOL File
- 77206-97-4.mol
5-FLUORO-2-NITROBENZAMIDE Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2924297099
N-Bromosuccinimide Price
- Product number
- F597593
- Product name
- 5-Fluoro-2-nitrobenzamide
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F597593
- Product name
- 5-Fluoro-2-nitrobenzamide
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- F597593
- Product name
- 5-Fluoro-2-nitrobenzamide
- Packaging
- 500mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- V7707
- Product name
- 5-Fluoro-2-nitrobenzamide
- Packaging
- 1g
- Price
- $81
- Updated
- 2021/12/16
- Product number
- A300132
- Product name
- 5-Fluoro-2-nitrobenzamide
- Purity
- 97%
- Packaging
- 250mg
- Price
- $18
- Updated
- 2021/12/16
5-FLUORO-2-NITROBENZAMIDE Chemical Properties,Usage,Production
Synthesis
394-02-5
77206-97-4
General procedure for the synthesis of 5-fluoro-2-nitrobenzamide from 5-fluoro-2-nitrobenzoyl chloride: anhydrous tetrahydrofuran (THF, 3 mL) solution of oxalyl chloride (1.83 g, 14.4 mmol) was added slowly and dropwise at 0 °C and under nitrogen protection to commercially available 5-fluoro-2-nitrobenzoic acid (1.78 g, 9.62 mmol) and N,N-dimethylformamide ( DMF, 40 mg) in a solution of anhydrous THF (10 mL). After the reaction mixture was stirred at room temperature for 1.5 h, the solvent was removed by vacuum evaporation to give 5-fluoro-2-nitrobenzoyl chloride (2.13 g) as a yellow oil. Subsequently, a solution of anhydrous THF (9 mL) of 5-fluoro-2-nitrobenzoyl chloride (1.53 g) was slowly added to pre-cooled 35% ammonia (30 mL) at room temperature. The reaction mixture was stirred for 45 min and extracted by adding dichloromethane (50 mL). The organic layer was separated and the aqueous layer was extracted once more with dichloromethane (50 mL). The combined organic phases were washed with saturated aqueous ammonium chloride solution (1 x 50 mL), dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated to dryness in vacuum to afford 5-fluoro-2-nitrobenzamide (1.04 g, 75% yield, liquid chromatographic purity >95%). Mass spectrometry analysis: [M+H]+=185.
References
[1] Patent: US2010/280268, 2010, A1. Location in patent: Page/Page column 46-47
[2] Patent: WO2008/74749, 2008, A1. Location in patent: Page/Page column 58
[3] Patent: WO2006/34491, 2006, A2. Location in patent: Page/Page column 43
[4] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2709 - 2721
[5] Patent: WO2014/143960, 2014, A1. Location in patent: Page/Page column 39-40
5-FLUORO-2-NITROBENZAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
5-FLUORO-2-NITROBENZAMIDE Suppliers
- Tel
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- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
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