ChemicalBook > CAS DataBase List > 3-BROMO-7-METHOXYQUINOLINE

3-BROMO-7-METHOXYQUINOLINE

Product Name
3-BROMO-7-METHOXYQUINOLINE
CAS No.
959121-99-4
Chemical Name
3-BROMO-7-METHOXYQUINOLINE
Synonyms
PO-2009050602-P-068;3-BROMO-7-METHOXYQUINOLINE;Quinoline, 3-bromo-7-methoxy-;2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethyl (4-nitrophenyl) carbonate
CBNumber
CB92467349
Molecular Formula
C10H8BrNO
Formula Weight
238.08
MOL File
959121-99-4.mol
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3-BROMO-7-METHOXYQUINOLINE Property

Boiling point:
318.3±22.0 °C(Predicted)
Density 
1.516±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
2.85±0.25(Predicted)
Appearance
Off-white to yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0364653
Product name
3-BROMO-7-METHOXYQUINOLINE
Purity
95.00%
Packaging
5MG
Price
$504.19
Updated
2021/12/16
AK Scientific
Product number
6577AC
Product name
3-Bromo-7-methoxyquinoline
Packaging
1g
Price
$978
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0364653
Product name
3-BROMO-7-METHOXYQUINOLINE
Purity
95.00%
Packaging
1G
Price
$1068.9
Updated
2021/12/16
Chemenu
Product number
CM145174
Product name
3-bromo-7-methoxyquinoline
Purity
95%
Packaging
1g
Price
$636
Updated
2021/12/16
Crysdot
Product number
CD11002891
Product name
3-Bromo-7-methoxyquinoline
Purity
95+%
Packaging
1g
Price
$666
Updated
2021/12/16
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3-BROMO-7-METHOXYQUINOLINE Chemical Properties,Usage,Production

Synthesis

2065-75-0

536-90-3

959121-99-4

To synthesize 3-bromo-7-methoxyquinoline, 1.80 g (12.3 mmol, 1.1 eq.) of 2-bromomalonaldehyde was first dissolved in 30 mL of ethanol, followed by the addition of 1.25 mL of m-aminoanisole. The reaction mixture was stirred overnight at room temperature, then 20 mL of acetic acid was added and stirring was continued at 100 °C for 10 days. Upon completion of the reaction, the solvent was removed under vacuum using a rotary evaporator. The residual solid was partitioned between water and ethyl acetate. The aqueous phase was adjusted to alkaline with aqueous ammonia solution and the insoluble solid was filtered out. The filtrate was extracted with ethyl acetate, the organic phases were combined and dried with anhydrous magnesium sulfate. After filtration, the organic solvent was removed by rotary evaporator under vacuum. The crude product was purified by column chromatography using hexane/ethyl acetate (8:2, v/v) as eluent, resulting in 700 mg of the target product in 20% yield. The product characterization data were as follows: molecular formula C10H8BrNO; molecular weight 237/239; 1H-NMR (CDCl3) δ 8.76 (d, J = 2.2 Hz, 1H), 8.15 (d, J = 2.2 Hz, 1H), 7.55 (d, J = 9.1 Hz, 1H), 7.32 (d, J = 2.5 Hz, 1H), 7.15 (dd , J = 2.5 Hz, J = 8.8 Hz, 1H), 3.88 (s, 3H, OMe); 13C-NMR (CDCl3) δ 159.9, 150.4, 147.1, 135.9, 126.9, 123.4, 119.9, 113.6, 106.3, 54.6; IR (cm-1 ): 2961, 1620, 1581, 1491, 1462 1581, 1491, 1462, 1417, 1261, 1027, 796; MS (ESI): m/z 238-240 (M + H)+.

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 7, p. 2158 - 2169
[2] Patent: US2010/204234, 2010, A1. Location in patent: Page/Page column 12
[3] Patent: WO2012/83165, 2012, A1. Location in patent: Page/Page column 98

3-BROMO-7-METHOXYQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BROMO-7-METHOXYQUINOLINE Suppliers

China 50 Germany 1 United States 3 Global 54
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
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View Lastest Price from 3-BROMO-7-METHOXYQUINOLINE manufacturers

Career Henan Chemical Co
Product
3-BROMO-7-METHOXYQUINOLINE 959121-99-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-12-18

959121-99-4, 3-BROMO-7-METHOXYQUINOLINERelated Search:

5-Bromo-2-methoxyphenol

  • 3-BROMO-7-METHOXYQUINOLINE
  • 2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethyl (4-nitrophenyl) carbonate
  • Quinoline, 3-bromo-7-methoxy-
  • PO-2009050602-P-068
  • 959121-99-4