6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL-

Product Name: 6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL-
CAS No.: 209984-30-5
Chemical Name: 6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL-
Synonyms: 5-Methyl-5H-dibenzo[b,d]azepin-6(7H);5-methyl-7H-benzo[d][1]benzazepin-6-one;N-methyl-5H-dibenzo[b,d]azepin-6(7H)-one;5,7-Dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one;5-methyl-5,7-dihydro-6H-dibenzo[b,d]azepin-6-one;6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL-;8-methyl-8-azatricyclo[9.4.0.0^{2,7}]pentadeca-1(15),2(7),3,5,11,13-hexaen-9-one;5-methyl-5H-dibenzo[b,d]azepin-6(7H)-one 5,7-Dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one
CBNumber: CB92467884
Molecular Formula: C15H13NO
Formula Weight: 223.27
MOL File: 209984-30-5.mol

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6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL- Property

Melting point:: 155-160℃
Boiling point:: 474.1±24.0 °C(Predicted)
Density: 1.166
storage temp.: Sealed in dry,Room Temperature
solubility: Dichloromethane, Methanol
form: Solid
pka: 0.49±0.20(Predicted)
color: Off-White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D449335
Product name: 5,7-Dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one
Packaging: 50mg
Price: $275
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22006
Product name: 5,7-Dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one
Packaging: 10mg
Price: $139.8
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22006
Product name: 5,7-Dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one
Packaging: 50mg
Price: $462
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0292341
Product name: 5-METHYL-5H-DIBENZO[B,D]AZEPIN-6(7H)-ONE
Purity: 95.00%
Packaging: 25MG
Price: $739.2
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22006
Product name: 5,7-Dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one
Packaging: 100mg
Price: $840
Updated: 2021/12/16

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6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL- Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

An intermediate in the production of γ-secretase inhibitors.

Synthesis

20011-90-9

74-88-4

209984-30-5

Step A - Synthesis of 7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one: Sodium hydride (0.295 g, 7.46 mmol) and 9.0 mL of anhydrous DMF were added to a dry round-bottomed flask, and stirred until completely dissolved. Subsequently, 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one (1.3 g, 6.22 mmol) was added, and the reaction mixture was stirred at 60 °C for 1 hour. Then, iodomethane (1.16 mL, 18.6 mmol) was slowly added dropwise and stirring was continued for 17 h under light protection. After completion of the reaction, the mixture was cooled to room temperature, diluted with a mixture of dichloromethane and water, washed sequentially with NaHSO4 solution and water, and the organic phase was dried with anhydrous Na2SO4. After concentration under reduced pressure, it was purified by fast column chromatography (silica gel, chloroform as eluent) to afford 0.885 g (63% yield) of the target compound, 5-methyl-5H-dibenz[b,d]azepin-6(7H)-one, as a colorless solid. Nuclear Magnetic Resonance Hydrogen Spectroscopy (1H-NMR, CDCl3) data: δ= 7.62 (d, 2H), 7.26-7.47 (m, 6H), 3.51 (m, 2H), 3.32 (s, 3H). Elemental analysis: C15H13NO (molecular weight = 223.27); mass spectrum (MH+) 223. calculated values: C, 80.69; H, 5.87; N, 6.27. measured values: C, 80.11; H, 5.95; N, 6.23.

References

[1] Organic Letters, 2008, vol. 10, # 21, p. 4871 - 4874
[2] Journal of Organic Chemistry, 2010, vol. 75, # 17, p. 5984 - 5993
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 22, p. 6392 - 6395
[4] Patent: EP951466, 2009, B1. Location in patent: Page/Page column 72
[5] Patent: US6958330, 2005, B1. Location in patent: Page/Page column 38-39

6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL- Preparation Products And Raw materials

Raw materials

Preparation Products

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6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL- Suppliers

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209984-30-5, 6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL-Related Search:

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