3-(iodomethyl)-1,1-dimethoxycyclobutane
- Product Name
- 3-(iodomethyl)-1,1-dimethoxycyclobutane
- CAS No.
- 1003013-83-9
- Chemical Name
- 3-(iodomethyl)-1,1-dimethoxycyclobutane
- Synonyms
- 3-(iodomethyl)-1,1-dimethoxycyclobutane;Cyclobutane, 3-(iodomethyl)-1,1-dimethoxy-
- CBNumber
- CB92470530
- Molecular Formula
- C7H13IO2
- Formula Weight
- 256.08
- MOL File
- 1003013-83-9.mol
3-(iodomethyl)-1,1-dimethoxycyclobutane Property
- storage temp.
- 2-8°C(protect from light)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B449143
- Product name
- 3-(Iodomethyl)-1,1-dimethoxycyclobutane
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- B449143
- Product name
- 3-(Iodomethyl)-1,1-dimethoxycyclobutane
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 074524
- Product name
- 3-(Iodomethyl)-1,1-dimethoxycyclobutane
- Purity
- 95+%
- Packaging
- 1g
- Price
- $899
- Updated
- 2021/12/16
- Product number
- CHM0167545
- Product name
- 3-(IODOMETHYL)-1,1-DIMETHOXYCYCLOBUTANE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $1034.88
- Updated
- 2021/12/16
- Product number
- X8487
- Product name
- 3-(Iodomethyl)-1,1-dimethoxycyclobutane
- Packaging
- 1g
- Price
- $1263
- Updated
- 2021/12/16
3-(iodomethyl)-1,1-dimethoxycyclobutane Chemical Properties,Usage,Production
Synthesis
175021-11-1
1003013-83-9
A solution of triphenylphosphine (2.42 g, 9.25 mmol) and imidazole (1.26 g, 18.49 mmol) in dichloromethane (20 mL) was added to a round-bottomed flask and cooled to 0°C in an ice bath. To this cooled solution was added iodine (2.35 g, 9.25 mmol). After the iodine was completely dissolved, a solution of (3,3-dimethoxycyclobutyl) methanol (1.04 g, 7.11 mmol) in dichloromethane (10 mL) was added. The reaction mixture was stirred at 0°C for 30 minutes, followed by continued stirring at 25°C for 2 hours. Upon completion of the reaction, the reaction was poured into ice-cold water (50 mL) and extracted with dichloromethane (2 × 30 mL). The organic layers were combined, washed with 1.0 N sodium thiosulfate solution (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by fast column chromatography (Merck silica gel 60, 230-400 mesh, elution gradient: 30% ethyl acetate/hexanes to 40% ethyl acetate/hexanes) afforded 3-(iodomethyl)-1,1-dimethoxycyclobutane (1.34 g, 74% yield) as a light yellow oil.1H NMR (300 MHz, CDCl3) δ ppm: 1.72- 1.81 (m, 2H, CH2), 2.28-2.53 (m, 3H, CH2 and CH), 3.14 (s, 3H, OCH3), 3.16 (s, 3H, OCH3), 3.29 (d, J = 7.7 Hz, 2H, ICH2).
References
[1] Patent: US2008/21032, 2008, A1. Location in patent: Page/Page column 83-84
3-(iodomethyl)-1,1-dimethoxycyclobutane Preparation Products And Raw materials
Raw materials
Preparation Products
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