ChemicalBook > CAS DataBase List > 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester

Uses

Product Name: 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester
CAS No.: 641569-97-3
Chemical Name: 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester
Synonyms: Nilotinib Impurity02;Nilotinib intermediate 2;Ethyl 4-methyl-3-((4-(pyridin-3-yl);Ethyl 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoate;Ethyl 4-Methyl-3-((4-(pyridin-3-yl)pyriMidin-2-yl)aMino)benzoate;4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester;Benzoic acid, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-, ethyl ester
CBNumber: CB92470969
Molecular Formula: C19H18N4O2
Formula Weight: 334.37
MOL File: 641569-97-3.mol

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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester Property

Density: 1.233
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
InChI: InChI=1S/C19H18N4O2/c1-3-25-18(24)14-7-6-13(2)17(11-14)23-19-21-10-8-16(22-19)15-5-4-9-20-12-15/h4-12H,3H2,1-2H3,(H,21,22,23)
InChIKey: SYTLMFJJRMLMIO-UHFFFAOYSA-N
SMILES: C(OCC)(=O)C1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: Z1740
Product name: 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoicacidethylester
Packaging: 5g
Price: $104
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0001072
Product name: 4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]BENZOIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $547.05
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0001072
Product name: 4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]BENZOIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 10G
Price: $4030.95
Updated: 2021/12/16

Ambeed

Product number: A230580
Product name: Ethyl4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate
Purity: 97%
Packaging: 1g
Price: $9
Updated: 2021/12/16

Ambeed

Product number: A230580
Product name: Ethyl4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate
Purity: 97%
Packaging: 5g
Price: $40
Updated: 2021/12/16

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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester Chemical Properties,Usage,Production

Uses

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic Acid Ethyl Ester-D6 is an intermediate in the synthesis of Nilotinib-d6 (N465303), which is the labeled analogue of Nilotinib, which might be useful in treatment of chronic myelogenous leukemia.

Description

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester is a pharmaceutical intermediate compound used in the preparation of nilotinib, a transactivation inhibitor targeting BCR-ABL, c-kit, and PDGF, which is used in the treatment of a variety of leukaemia, including chronic granulocytic leukaemia (CML). Chronic granulocytic leukaemia (CML) is caused by the BCR-ABL oncogene. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein.

Uses

Ethyl 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoate is used in preparation of the Smo inhibitor and synthesis and their application.

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester manufacturers

Career Henan Chemical Co

Product: 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester 641569-97-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-13

641569-97-3, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl esterRelated Search:

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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester

Ethyl 4-Methyl-3-((4-(pyridin-3-yl)pyriMidin-2-yl)aMino)benzoate

Benzoic acid, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-, ethyl ester

Ethyl 4-methyl-3-((4-(pyridin-3-yl)

Nilotinib intermediate 2

Ethyl 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoate

Nilotinib Impurity02

641569-97-3