5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine
- Product Name
- 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine
- CAS No.
- 929617-30-1
- Chemical Name
- 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine
- Synonyms
- 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine;5-bromo-3-methyl-2h-pyrazolo[3,4-c]pyridine;1H-Pyrazolo[3,4-c]pyridine,5-broMo-3-Methyl-
- CBNumber
- CB92471315
- Molecular Formula
- C7H6BrN3
- Formula Weight
- 212.05
- MOL File
- 929617-30-1.mol
5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine Property
- Boiling point:
- 384.1±37.0 °C(Predicted)
- Density
- 1.755
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 10.07±0.40(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B697573
- Product name
- 5-Bromo-3-methyl-1h-pyrazolo[3,4-c]pyridine
- Packaging
- 25mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- B697573
- Product name
- 5-Bromo-3-methyl-1h-pyrazolo[3,4-c]pyridine
- Packaging
- 250mg
- Price
- $635
- Updated
- 2021/12/16
- Product number
- FB142159
- Product name
- 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine
- Packaging
- 50mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- FB142159
- Product name
- 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine
- Packaging
- 100mg
- Price
- $98
- Updated
- 2021/12/16
- Product number
- FB142159
- Product name
- 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine
- Packaging
- 250mg
- Price
- $195
- Updated
- 2021/12/16
5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine Chemical Properties,Usage,Production
Synthesis
1114523-56-6
929617-30-1
General procedure for the synthesis of 5-bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine from 1-(2-bromo-5-fluoro-4-pyridinyl)ethanone: 50 mL of anhydrous ethylene glycol was added to dissolve 1-(2-bromo-5-fluoro-4-pyridinyl)ethanone (8.2 g, 37.6 mmol) in a 150 mL pressure flask. Subsequently, anhydrous hydrazine (1.24 mL, 39.5 mmol) was added slowly dropwise via syringe. The light yellow mixture obtained by stirring was sealed and the reaction was heated at 165°C. After 3.5 h, the orange-brown reaction mixture was removed from the heat source and cooled to room temperature. The reaction mixture was poured into a stirred mixture of 300 g of ice water (1:1), at which point a solid precipitated. After continued stirring for 10 minutes, the heterogeneous mixture was vacuum filtered. The collected solid was dried under vacuum to give a high purity off-white solid product (7.9 g, 99% yield), which could be used in subsequent reactions without further purification. Product characterization data: 1H NMR (CD3OD-d4) δ 8.73 (s, 1H), 7.98 (s, 1H), 2.59 (s, 3H); LC/MS (MH+) = 211.5, 213.7; retention time (RT) = 1.33 min.
References
[1] Tetrahedron Letters, 2009, vol. 50, # 4, p. 383 - 385
[2] Patent: WO2009/32651, 2009, A1. Location in patent: Page/Page column 8; 32
[3] Patent: WO2016/26549, 2016, A1. Location in patent: Page/Page column 47
[4] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 1324; 1328
5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine manufacturers
- Product
- 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine 929617-30-1
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 1kg; 10kg; 25kg
- Release date
- 2020-01-07