Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate
- Product Name
- Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate
- CAS No.
- 867065-53-0
- Chemical Name
- Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate
- Synonyms
- Ethyl 2-(4-Boc-1-piperazinyl)thiazole-4-carboxylate;tert-butyl 4-(4-(ethoxycarbonyl)thiazol-2-yl)piperazine-1-carboxylate;Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate;4-(4-Ethoxycarbonylthiazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester;ethyl 2-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-1,3-thiazole-4-carboxylate;1-Piperazinecarboxylic acid, 4-[4-(ethoxycarbonyl)-2-thiazolyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB92471421
- Molecular Formula
- C15H23N3O4S
- Formula Weight
- 341.43
- MOL File
- 867065-53-0.mol
Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate Property
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E921658
- Product name
- Ethyl2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate
- Packaging
- 100mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- E921658
- Product name
- Ethyl2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate
- Packaging
- 250mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- 073702
- Product name
- Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- W8904
- Product name
- Ethyl2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate
- Packaging
- 5g
- Price
- $743
- Updated
- 2021/12/16
- Product number
- CHM0167204
- Product name
- ETHYL-2-(4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL)THIAZOLE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $862.79
- Updated
- 2021/12/16
Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate Chemical Properties,Usage,Production
Synthesis
100367-77-9
57260-71-6
867065-53-0
General procedure for the synthesis of ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate from ethyl 2-bromothiazole-4-carboxylate and N-BOC-piperazine: ethyl N-BOC-piperazine (1.8 g, 10 mmol), ethyl 2-bromothiazole-4-carboxylate (2.36 g, 10 mmol) and N,N-diisopropylethylamine (DIPEA. 2.02 g, 20 mmol) were dissolved in 1,4-dioxane (15 mL). The reaction mixture was stirred at 100°C overnight. Upon completion of the reaction, it was extracted with ethyl acetate (EA) and the organic phase was washed with saturated saline. Purification by fast column chromatography (eluent: petroleum ether/ethyl acetate = 5:1 to 3:1) afforded a yellow solid product (3.0 g, 88% yield).
References
[1] Patent: US2018/141923, 2018, A1. Location in patent: Paragraph 0599; 0600; 0601
[2] Patent: WO2008/83238, 2008, A2. Location in patent: Page/Page column 112
[3] Patent: WO2018/26890, 2018, A1. Location in patent: Paragraph 0479; 0480
Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate Suppliers
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