ChemicalBook > CAS DataBase List > 2-chloro-Thiazolo[4,5-b]pyridine

2-chloro-Thiazolo[4,5-b]pyridine

Product Name: 2-chloro-Thiazolo[4,5-b]pyridine
CAS No.: 152170-30-4
Chemical Name: 2-chloro-Thiazolo[4,5-b]pyridine
Synonyms: 2-chlorothiazolo[4;2-Chlorthiazolo[4,5-b]pyridine;2-chloro-Thiazolo[4,5-b]pyridine;Thiazolo[4,5-b]pyridine, 2-chloro-
CBNumber: CB92473344
Molecular Formula: C6H3ClN2S
Formula Weight: 170.62
MOL File: 152170-30-4.mol

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2-chloro-Thiazolo[4,5-b]pyridine Property

Boiling point:: 263.5±13.0 °C(Predicted)
Density: 1.531±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.95±0.50(Predicted)
Appearance: Light brown to brown Solid
InChI: InChI=1S/C6H3ClN2S/c7-6-9-5-4(10-6)2-1-3-8-5/h1-3H
InChIKey: RSDZXVRUWGEPQG-UHFFFAOYSA-N
SMILES: C12N=C(Cl)SC1=CC=CN=2

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C380648
Product name: 2-Chlorothiazolo[4,5-b]pyridine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 073760
Product name: 2-Chlorothiazolo[4,5-b]pyridine hydrochloride
Purity: 95+%
Packaging: 250mg
Price: $145
Updated: 2021/12/16

Apolloscientific

Product number: OR903587
Product name: 2-Chlorothiazolo[4,5-b]pyridine
Purity: 97%
Packaging: 250mg
Price: $218
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H70-5-2C
Product name: 2-Chlorothiazolo[4,5-b]pyridine
Purity: 97%
Packaging: 250mg
Price: $240
Updated: 2021/12/16

Matrix Scientific

Product number: 073760
Product name: 2-Chlorothiazolo[4,5-b]pyridine hydrochloride
Purity: 95+%
Packaging: 1g
Price: $363
Updated: 2021/12/16

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2-chloro-Thiazolo[4,5-b]pyridine Chemical Properties,Usage,Production

Synthesis

99158-61-9

152170-30-4

The general procedure for the synthesis of 2-chlorothiazolo[4,5-b]pyridine from thiazolo[4,5-b]pyridine-2(3H)-thione was as follows: sulfuryl chloride (3.32 mL, 40.8 mmol) was slowly added to a dichloromethane (0.5 mL) suspension of thiazolo[4,5-b]pyridine-2-thiol (343 mg, 2.039 mmol). The reaction mixture was stirred at 50 °C for 2 h, followed by continued stirring at room temperature overnight. Upon completion of the reaction, ice water was added to the yellow suspension and stirred at room temperature for 15 minutes to quench the excess sulfuryl chloride. Subsequently, the pH was adjusted to 10-12 by adding ethyl acetate (EtOAc) and 4.0 N sodium hydroxide (NaOH) solution.The organic layer was separated, washed with saturated brine and dried over anhydrous sodium sulfate. After concentration under reduced pressure to remove the solvent, the crude product was dissolved in a small amount of chloroform and purified by column chromatography on silica gel (12 g silica gel), eluting first with 5% eluent for 3 min and then using a 12% gradient elution (5% to 60%). The fractions containing the target product were combined and concentrated under reduced pressure to give Intermediate 9A (265 mg, 1.553 mmol, 76% yield) as a white solid. The structure of the product was confirmed by 1H NMR (500 MHz, chloroform-d): δ 8.76 (dd, J = 5.0, 1.7 Hz, 1H), 8.19 (dd, J = 8.0, 1.7 Hz, 1H), 7.39 (dd, J = 8.0, 4.7 Hz, 1H); LC-MS analysis (Method A): retention time (RT) = 1.22 min, mass spectrum (ESI) m/z: 171 and 173 ([M + H]+).

References

[1] Patent: WO2018/13774, 2018, A1. Location in patent: Page/Page column 307
[2] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 92

2-chloro-Thiazolo[4,5-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-chloro-Thiazolo[4,5-b]pyridine manufacturers

Career Henan Chemical Co

Product: 2-chloro-Thiazolo[4,5-b]pyridine 152170-30-4
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

152170-30-4, 2-chloro-Thiazolo[4,5-b]pyridineRelated Search:

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152170-30-4

Heterocycle-Pyridine series