ChemicalBook > CAS DataBase List > 6-Chloro-5-fluoro-nicotinic acid

6-Chloro-5-fluoro-nicotinic acid

Product Name
6-Chloro-5-fluoro-nicotinic acid
CAS No.
38186-86-6
Chemical Name
6-Chloro-5-fluoro-nicotinic acid
Synonyms
5-fluoro-6-chloronicotinic acid;6-Chloro-5-fluoro-nicotinic acid;6-Chloro-5-fluoropyridine-3-carboxylic acid;6-Chloro-5-fluoro-3-pyridinecarboxylic acid;2-Chloro-3-fluoropyridine-5-carboxylic acid;6-Chloro-5-fluoropyridine-3-carboyxlic acid;3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-5-FLUORO-;6-chloro-5-fluoro-pyridine-3-carboxylic acid - [C86634];6-Chloro-5-fluoropyridine-3-carboxylic acid, 5-Carboxy-2-chloro-3-fluoropyridine;6-Chloro-5-fluoropyridine-3-carboxylic acid, 3-Carboxy-6-chloro-5-fluoropyridine
CBNumber
CB92473733
Molecular Formula
C6H3ClFNO2
Formula Weight
175.54
MOL File
38186-86-6.mol
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6-Chloro-5-fluoro-nicotinic acid Property

Boiling point:
314.2±37.0 °C(Predicted)
Density 
1.576±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
2.90±0.10(Predicted)
form 
powder
color 
Off-white
InChI
InChI=1S/C6H3ClFNO2/c7-5-4(8)1-3(2-9-5)6(10)11/h1-2H,(H,10,11)
InChIKey
YICIHICLGVXCGP-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=C(F)C=C1C(O)=O
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific
Product number
PC10650
Product name
6-Chloro-5-fluoronicotinicacid
Packaging
250mg
Price
$80
Updated
2021/12/16
SynQuest Laboratories
Product number
4H21-7-04
Product name
6-Chloro-5-fluoronicotinic acid
Packaging
250mg
Price
$88
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
C12734
Product name
6-Chloro-5-fluoropyridine-3-carboxylicacid
Purity
95%
Packaging
1g
Price
$90
Updated
2021/12/16
Matrix Scientific
Product number
102789
Product name
6-Chloro-5-fluoronicotinic acid
Purity
98%
Packaging
500mg
Price
$116
Updated
2021/12/16
Apolloscientific
Product number
PC10650
Product name
6-Chloro-5-fluoronicotinicacid
Packaging
1g
Price
$203
Updated
2021/12/16
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6-Chloro-5-fluoro-nicotinic acid Chemical Properties,Usage,Production

Synthesis

34552-15-3

38186-86-6

2-Chloro-3-fluoro-5-methylpyridine (512 mg, 3.5 mmol) was used as starting material and dissolved in a solvent mixture of pyridine (2.5 mL) and water (2.5 mL). Potassium permanganate (1.1 g, 6.9 mmol) was added to this solution in batches and after the first addition, the reaction mixture was heated to 100 °C and stirred for 1 hour. Subsequently, additional potassium permanganate (totaling 3.3 g, 20.7 mmol) was added in two batches over a period of 2 hours. During the reaction, if solids accumulate in the condenser, it can be washed with water and pyridine. After continued stirring at 100 °C for 1 h, the reaction mixture was cooled to room temperature. The reaction was quenched with saturated aqueous Na2S2O3 and stirred for 30 minutes. The reaction mixture was filtered and the filtrate was acidified to pH 2 with 1.5 M HCl. The aqueous phase was extracted with EtOAc (3×), the organic phases were combined and washed with brine (1×), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by rapid chromatography on silica gel, using a gradient elution of 90% to 70% petroleum ether-EtOAc to afford 5-fluoro-6-chloronicotinic acid as a white solid (300 mg, 49% yield).

References

[1] Patent: WO2018/154118, 2018, A2. Location in patent: Page/Page column 106; 107
[2] Patent: WO2010/132016, 2010, A1. Location in patent: Page/Page column 91

6-Chloro-5-fluoro-nicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-5-fluoro-nicotinic acid Suppliers

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View Lastest Price from 6-Chloro-5-fluoro-nicotinic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
6-Chloro-5-fluoro-nicotinic acid 38186-86-6
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100kg
Release date
2025-08-18
Career Henan Chemical Co
Product
6-Chloro-5-fluoro-nicotinic acid 38186-86-6
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2019-12-31

38186-86-6, 6-Chloro-5-fluoro-nicotinic acidRelated Search:

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  • 6-Chloro-5-fluoro-nicotinic acid
  • 5-fluoro-6-chloronicotinic acid
  • 6-Chloro-5-fluoropyridine-3-carboxylic acid
  • 6-Chloro-5-fluoropyridine-3-carboxylic acid, 3-Carboxy-6-chloro-5-fluoropyridine
  • 6-Chloro-5-fluoropyridine-3-carboxylic acid, 5-Carboxy-2-chloro-3-fluoropyridine
  • 3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-5-FLUORO-
  • 6-Chloro-5-fluoropyridine-3-carboyxlic acid
  • 2-Chloro-3-fluoropyridine-5-carboxylic acid
  • 6-Chloro-5-fluoro-3-pyridinecarboxylic acid
  • 6-chloro-5-fluoro-pyridine-3-carboxylic acid - [C86634]
  • 38186-86-6
  • 628691-93-1