ChemicalBook > CAS DataBase List > 2-Bromo-N,N-dimethylacetamide

2-Bromo-N,N-dimethylacetamide

Product Name: 2-Bromo-N,N-dimethylacetamide
CAS No.: 5468-77-9
Chemical Name: 2-Bromo-N,N-dimethylacetamide
Synonyms: N-dimethylacetamide;N,N-dimethyl-bromoacetamide;2-Bromo-N,N-dimethylacetamide;2-bromo-N,N-dimethyl-ethanamide;Acetamide, 2-bromo-N,N-dimethyl-;2-BROMO-N,N-DIMETHYLACETAMIDE 95%;2-Bromo-N,N-dimethylacetamide
CBNumber: CB92478031
Molecular Formula: C4H8BrNO
Formula Weight: 166.02
MOL File: 5468-77-9.mol

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2-Bromo-N,N-dimethylacetamide Property

Melting point:: 72-73 °C(Solv: toluene (108-88-3))
Boiling point:: 63-65 °C(Press: 1 Torr)
Density: 1.5412
refractive index: 1.5097
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.04±0.70(Predicted)
form: liquid
color: Colourless to light yellow
InChI: InChI=1S/C4H8BrNO/c1-6(2)4(7)3-5/h3H2,1-2H3
InChIKey: QPIOVNJLOVNTMW-UHFFFAOYSA-N
SMILES: C(N(C)C)(=O)CBr

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Safety

RIDADR: UN2735
HazardClass: IRRITANT
HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B6352
Product name: 2-Bromo-N,N-dimethylacetamide
Purity: min. 98.0 %
Packaging: 1G
Price: $57
Updated: 2025/07/31

TCI Chemical

Product number: B6352
Product name: 2-Bromo-N,N-dimethylacetamide
Purity: min. 98.0 %
Packaging: 5G
Price: $171
Updated: 2025/07/31

TRC

Product number: B695735
Product name: 2-Bromo-n,n-dimethylacetamide
Packaging: 100mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: J96313
Product name: 2-Bromo-N,N-dimethylacetamide
Packaging: 1g
Price: $25
Updated: 2021/12/16

Matrix Scientific

Product number: 035114
Product name: 2-Bromo-N,N-dimethylacetamide
Packaging: 1g
Price: $37
Updated: 2021/12/16

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2-Bromo-N,N-dimethylacetamide Chemical Properties,Usage,Production

Synthesis

506-59-2

598-21-0

5468-77-9

To a stirred solution of N,N-dimethylamine hydrochloride (2 g, 24.52 mmol) in dichloromethane (20 mL) was added sequentially N,N-diisopropylethylamine (DIPEA, 12.6 mL, 73.55 mmol) and bromoacetobromide (9.89 g, 19.04 mmol) under an inert atmosphere, maintaining the reaction temperature at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 3 hours. The reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with water (50 mL) and extracted with dichloromethane (2 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel fast column chromatography with 30% ethyl acetate/hexane as eluent to give N,N-dimethyl-bromoacetamide (1.7 g, 42% yield) as a brown liquid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 3.86 (s, 2H), 3.10 (s, 3H), 2.99 (s, 3H); LC-MS purity: 71.2%; (M + 2) measured value = 168 (column: XBridge C-18, 50 x 3.0 mm, 3.5 μm; mobile phase: 5 mM NH4OAc ACN; flow rate: 0.8 mL/min).

References

[1] Tetrahedron, 2000, vol. 56, # 42, p. 8253 - 8262
[2] Journal of Organic Chemistry, 2015, vol. 80, # 11, p. 5415 - 5427
[3] Patent: WO2015/48301, 2015, A1. Location in patent: Paragraph 00435
[4] Tetrahedron, 2012, vol. 68, # 24, p. 4710 - 4718
[5] Angewandte Chemie - International Edition, 2013, vol. 52, # 19, p. 5079 - 5084

2-Bromo-N,N-dimethylacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-N,N-dimethylacetamide manufacturers

Career Henan Chemical Co

Product: 2-Bromo-N,N-dimethylacetamide 5468-77-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-09

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