3-Piperidinecarboxylic acid benzyl ester
- Product Name
- 3-Piperidinecarboxylic acid benzyl ester
- CAS No.
- 97231-90-8
- Chemical Name
- 3-Piperidinecarboxylic acid benzyl ester
- Synonyms
- benzyl piperidine-3-carboxylate;3-Piperidinecarboxylic acid benzyl ester;piperidine-3-carboxylic acid benzyl ester;3-piperidinecarboxylic acid (phenylmethyl) ester;RS-3-Piperidinecarboxylic acid phenylmethyl ester
- CBNumber
- CB92485013
- Molecular Formula
- C13H17NO2
- Formula Weight
- 219.28
- MOL File
- 97231-90-8.mol
3-Piperidinecarboxylic acid benzyl ester Property
- Density
- 1.092
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B289190
- Product name
- BenzylPiperidine-3-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 6811AC
- Product name
- Benzylpiperidine-3-carboxylate
- Packaging
- 5g
- Price
- $433
- Updated
- 2021/12/16
- Product number
- CHM0391938
- Product name
- BENZYL PIPERIDINE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.77
- Updated
- 2021/12/16
- Product number
- A336575
- Product name
- Benzylpiperidine-3-carboxylate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $27
- Updated
- 2021/12/16
- Product number
- A336575
- Product name
- Benzylpiperidine-3-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $42
- Updated
- 2021/12/16
3-Piperidinecarboxylic acid benzyl ester Chemical Properties,Usage,Production
Synthesis
139985-95-8
97231-90-8
The general procedure for the synthesis of benzyl 3-piperidinecarboxylate from benzyl 1-Boc-piperidine-3-carboxylate was as follows: benzyl 1-(tert-butoxycarbonyl)piperidinecarboxylate (7.11 g, 22.3 mmol) was dissolved in dichloromethane (20 mL) and trifluoroacetic acid (43 mL, 558 mmol) was added slowly. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and water was added to the residue, followed by dropwise addition of 1 mol/L aqueous sodium hydroxide to adjust the pH to basic. The aqueous phase was extracted with ethyl acetate and the organic layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to give benzyl 3-piperidinecarboxylate as a yellow oil (5.97 g, quantitative yield). The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 1.45-1.70 (3H, m), 1.92-1.96 (1H, m), 2.59-2.69 (2H, m), 2.81 (1H, t, J = 9.8 Hz), 2.94-3.02 (1H, m), 3.21 (1H, dd, J = 12.6, 3.3 Hz), 5.10 (2H, d, J = 3.1 Hz), 7.27-7.38 (5H, m). Mass spectral analysis showed the molecular ion peak (EI+, m/z): 219 (M+).
References
[1] Patent: EP1780210, 2007, A1. Location in patent: Page/Page column 53
[2] Patent: WO2007/62007, 2007, A1. Location in patent: Page/Page column 87-88
3-Piperidinecarboxylic acid benzyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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