Methyl 2-amino-4-benzyloxy-5-methoxybenzoate
- Product Name
- Methyl 2-amino-4-benzyloxy-5-methoxybenzoate
- CAS No.
- 61032-42-6
- Chemical Name
- Methyl 2-amino-4-benzyloxy-5-methoxybenzoate
- Synonyms
- Methyl 2-amino-4-benzyloxy-5-methoxybenzoate;methyl 2-amino-5-methoxy-4-phenylmethoxybenzoate;2-Amino-4-benzyloxy-5-methoxybenzoic acid methyl ester;Benzoic acid, 2-amino-5-methoxy-4-(phenylmethoxy)-, methyl ester
- CBNumber
- CB92487709
- Molecular Formula
- C16H17NO4
- Formula Weight
- 287.31
- MOL File
- 61032-42-6.mol
Methyl 2-amino-4-benzyloxy-5-methoxybenzoate Property
- Melting point:
- 131-132℃
- Boiling point:
- 450.0±40.0 °C(Predicted)
- Density
- 1.205
- storage temp.
- 2-8°C(protect from light)
- pka
- 2.67±0.10(Predicted)
- Appearance
- Off-white to gray Solid
N-Bromosuccinimide Price
- Product number
- M292985
- Product name
- Methyl2-Amino-4-benzyloxy-5-methoxybenzoate
- Packaging
- 1g
- Price
- $550
- Updated
- 2021/12/16
- Product number
- 126318
- Product name
- Methyl2-amino-4-(benzyloxy)-5-methoxybenzoate
- Purity
- >95%
- Packaging
- 1g
- Price
- $630
- Updated
- 2021/12/16
- Product number
- CS-M0195
- Product name
- methyl2-amino-4-(benzyloxy)-5-methoxybenzoate
- Purity
- >97.0%
- Packaging
- 5g
- Price
- $660
- Updated
- 2021/12/16
- Product number
- CHM0392910
- Product name
- METHYL-2-AMINO-4-(BENZYLOXY)-5-METHOXYBENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.56
- Updated
- 2021/12/16
- Product number
- CS-M0195
- Product name
- methyl2-amino-4-(benzyloxy)-5-methoxybenzoate
- Purity
- >97.0%
- Packaging
- 10g
- Price
- $1271
- Updated
- 2021/12/16
Methyl 2-amino-4-benzyloxy-5-methoxybenzoate Chemical Properties,Usage,Production
Uses
Methyl 2-Amino-4-benzyloxy-5-methoxybenzoate can be used as reactant/reagent in preparation of cyanoquinolines as protein tyrosine kinase inhibitors.
Synthesis
61032-41-5
61032-42-6
Example 6 (Synthesis of methyl 2-amino-4-benzyloxy-5-methoxybenzoate): In a glass reactor equipped with a stirrer, a thermometer, a reflux condenser tube, and a hydrogen balloon, 4.0 g (12.6 mmol) of methyl 4-benzyloxy-5-methoxy-2-nitrobenzoate, 0.2 g of a 3 wt% platinum/carbon catalyst (60% moisture content, manufactured by NE CHEMCAT CORPORATION) and 20 mL of dimethoxyethane. The reaction was stirred at room temperature for 7 hours under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was allowed to stand for 10 days, followed by filtration. The filtrate was concentrated under reduced pressure to give 3.17 g methyl 2-amino-4-benzyloxy-5-methoxybenzoate as a light brown solid (isolated yield: 87%). The physical property data of the product were as follows: 1H-NMR (CDCl3, δ/ppm): 3.81 (3H, s), 3.83 (3H, s), 5.09 (2H, s), 5.37 (2H, br s), 6.15 (1H, s), 7.31-7.41 (6H, m); CI-MS (m/e): 287 (M+).
References
[1] Patent: CN105541736, 2016, A. Location in patent: Paragraph 0044; 0047
[2] Organic Letters, 1999, vol. 1, # 11, p. 1835 - 1837
[3] Chemical Communications, 2016, vol. 52, # 87, p. 12869 - 12872
[4] Patent: EP2123627, 2009, A1. Location in patent: Page/Page column 6-7
[5] Patent: US2009/76044, 2009, A1. Location in patent: Page/Page column 26-27
Methyl 2-amino-4-benzyloxy-5-methoxybenzoate Preparation Products And Raw materials
Raw materials
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View Lastest Price from Methyl 2-amino-4-benzyloxy-5-methoxybenzoate manufacturers
- Product
- Methyl 2-amino-4-benzyloxy-5-methoxybenzoate 61032-42-6
- Price
- US $10.00/g
- Min. Order
- 10g
- Purity
- 0.99
- Supply Ability
- 1ton
- Release date
- 2024-10-31
- Product
- Methyl 2-amino-4-benzyloxy-5-methoxybenzoate 61032-42-6
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 100kg; 1000kg
- Release date
- 2019-12-24