3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
- Product Name
- 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
- CAS No.
- 1083057-14-0
- Chemical Name
- 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
- Synonyms
- tert-Butyl 3-(6-aMino-3-Methylpyridin-2-yl)benzoate;EOS-61004;VX-809 intermediate;tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoat;3-(6-amino-3-methylpyridine-2-yl) tert-butyl benzoate;3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester;3-(6-Amino-3-methyl-pyridin-2-yl)-benzoic acid tert-butyl es...;Tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate(For export only);Benzoic acid, 3-(6-aMino-3-Methyl-2-pyridinyl)-, 1,1-diMethylethyl ester
- CBNumber
- CB92489657
- Molecular Formula
- C17H20N2O2
- Formula Weight
- 284.35
- MOL File
- 1083057-14-0.mol
3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester Property
- Boiling point:
- 439.7±45.0 °C(Predicted)
- Density
- 1.119±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 5.95±0.34(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Z3873
- Product name
- tert-Butyl3-(6-amino-3-methylpyridin-2-yl)benzoate
- Packaging
- 100mg
- Price
- $127
- Updated
- 2021/12/16
- Product number
- CS-M2542
- Product name
- Benzoicacid,3-(6-amino-3-methyl-2-pyridinyl)-,1,1-dimethylethylester
- Purity
- 98.13%
- Packaging
- 1g
- Price
- $208
- Updated
- 2021/12/16
- Product number
- CHM0394020
- Product name
- TERT-BUTYL-3-(6-AMINO-3-METHYLPYRIDIN-2-YL)BENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.21
- Updated
- 2021/12/16
- Product number
- 35111
- Product name
- tert-Butyl3-(6-amino-3-methylpyridin-2-yl)benzoate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $720
- Updated
- 2021/12/16
- Product number
- CS-M2542
- Product name
- Benzoicacid,3-(6-amino-3-methyl-2-pyridinyl)-,1,1-dimethylethylester
- Purity
- 98.13%
- Packaging
- 250mg
- Price
- $77
- Updated
- 2021/12/16
3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester Chemical Properties,Usage,Production
Synthesis
1083057-13-9
1083057-14-0
The general procedure for the synthesis of tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate from 2-(3-(tert-butoxycarbonyl)phenyl)-3-methylpyridine-1-oxide is as follows: a mixture of 2-(3-(tert-butoxycarbonyl)phenyl)-3-methylpyridine-1-oxide (1 eq.) and pyridine (4 eq.) in acetonitrile (8 vol.) was heated to 70 °C. A solution of methylsulfonic anhydride (1.5 eq.) in acetonitrile (2 vol.) was slowly added through the addition funnel over 50 min, and the reaction temperature was controlled below 75 °C. After the addition was completed, stirring of the reaction mixture was continued for 0.5 hours. The reaction mixture was then cooled to room temperature. Ethanolamine (10 equivalents) was added through the addition funnel and after stirring the reaction for 2 hours, water (6 volumes) was added and the mixture was cooled to 10°C. After continued stirring for not less than 3 hours, the solid product was collected by filtration. The solid was washed sequentially with water (3 volumes), a 2:1 acetonitrile/water mixture (3 volumes) and acetonitrile (2 x 1.5 volumes). The solid was dried in a vacuum oven at 50 °C to constant weight (less than 1% change in weight) and kept under a slight stream of nitrogen to give tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate as a reddish yellow solid in 53% yield.
References
[1] Patent: WO2009/76142, 2009, A2. Location in patent: Page/Page column 54
[2] Patent: WO2009/73757, 2009, A1. Location in patent: Page/Page column 23
[3] Patent: WO2010/37066, 2010, A2. Location in patent: Page/Page column 12; 28-29
[4] Patent: US2013/186801, 2013, A1. Location in patent: Paragraph 0371; 0372
[5] Patent: WO2013/185112, 2013, A1. Location in patent: Paragraph 00569
3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester Preparation Products And Raw materials
Raw materials
Preparation Products
3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester manufacturers
- Product
- 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester 183057-14-0
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-07
- Product
- 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester 1083057-14-0
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g； 1kg; 25kg
- Release date
- 2020-01-10
- Product
- 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester 1083057-14-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-17