6,8-dichloro-2,7-naphthyridin-1-ol
- Product Name
- 6,8-dichloro-2,7-naphthyridin-1-ol
- CAS No.
- 950746-21-1
- Chemical Name
- 6,8-dichloro-2,7-naphthyridin-1-ol
- Synonyms
- 6,8-dichloro-2,7-naphthyridin-1-ol;6,8-Dichloro-2,7-naphthyridin-1(2H);6,8-dichloro-2H-2,7-naphthyridin-1-one;6,8-Dichloro-2,7-naphthyridin-1(2H)-one;6,8-Dichloro-2,7-naphthyridine-1(2H)-one;6,8-Dichloro-1-hydroxy-2,7-naphthyridine;2,7-Naphthyridin-1(2H)-one, 6,8-dichloro-
- CBNumber
- CB92490132
- Molecular Formula
- C8H4Cl2N2O
- Formula Weight
- 215.04
- MOL File
- 950746-21-1.mol
6,8-dichloro-2,7-naphthyridin-1-ol Property
- Density
- 1.544
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
N-Bromosuccinimide Price
- Product number
- HCH0367629
- Product name
- 6,8-DICHLORO-2,7-NAPHTHYRIDIN-1(2H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.45
- Updated
- 2021/12/16
- Product number
- 094867
- Product name
- 6,8-Dichloro-2,7-naphthyridin-1(2H)-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $515
- Updated
- 2021/12/16
- Product number
- 6331AC
- Product name
- 6,8-Dichloro-2,7-naphthyridin-1(2H)-one
- Packaging
- 1g
- Price
- $674
- Updated
- 2021/12/16
- Product number
- 094867
- Product name
- 6,8-Dichloro-2,7-naphthyridin-1(2H)-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1143
- Updated
- 2021/12/16
- Product number
- 6331AC
- Product name
- 6,8-Dichloro-2,7-naphthyridin-1(2H)-one
- Packaging
- 100mg
- Price
- $217
- Updated
- 2021/12/16
6,8-dichloro-2,7-naphthyridin-1-ol Chemical Properties,Usage,Production
Synthesis
1175559-53-1
950746-21-1
Step 4: To a sealed reaction tube was added 2,6-dichloro-4-[(1E)-2-(dimethylamino)vinyl]pyridine-3-carbonitrile (4.0 g, 16.6 mmol) and concentrated hydrochloric acid (20 mL). The reaction mixture was stirred at 45 °C for 18 hours. After completion of the reaction, it was cooled to room temperature and ice water was added to the reaction solution to form a yellow slurry. The precipitate was collected by filtration, washed sequentially with cold water, ether and ethyl acetate, and then dried under vacuum to afford 6,8-dichloro-2,7-naphthyridin-1(2H)-one as a pale yellow solid (80% yield). Mass spectrum (MS) m/z: 215.0 (M + 1). 1H NMR (300 MHz, DMSO-d6): δ 11.75 (s, 1H), 7.76 (s, 1H), 7.50 (t, J = 6.6 Hz, 1H), 6.52 (d, J = 6.6 Hz, 1H).
References
[1] Patent: WO2013/185353, 2013, A1. Location in patent: Page/Page column 21
[2] Patent: WO2014/165232, 2014, A1. Location in patent: Paragraph 0178; 0179
[3] Patent: US2015/119387, 2015, A1. Location in patent: Paragraph 0179; 0180
[4] Patent: JP2017/95498, 2017, A. Location in patent: Paragraph 0085; 0086
[5] Patent: CN104530042, 2017, B. Location in patent: Paragraph 0171; 0183; 0184; 0185
6,8-dichloro-2,7-naphthyridin-1-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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