N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide
- Product Name
- N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide
- CAS No.
- 127446-34-8
- Chemical Name
- N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide
- Synonyms
- N-(6-Chloro-3-formylpyridin-2-yl)pivalamide;N-(6-Chloro-3-formylpyridin-2-yl)pivalamide?New;N-(6-chloro-3-formyl-2-pyridyl)-2,2-dimethyl-propanamide;N-(6-chloro-3-formylpyridin-2-yl)-2,2-dimethylpropanamide;Propanamide, N-(6-chloro-3-formyl-2-pyridinyl)-2,2-dimethyl-;N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide
- CBNumber
- CB92491674
- Molecular Formula
- C11H13ClN2O2
- Formula Weight
- 240.69
- MOL File
- 127446-34-8.mol
N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide Property
- Melting point:
- 137-139℃
- Density
- 1.273
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C383700
- Product name
- N-(6-Chloro-3-Formylpyridin-2-Yl)Pivalamide
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FC142055
- Product name
- N-(6-Chloro-3-formylpyridin-2-yl)pivalamide
- Packaging
- 250mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- FC142055
- Product name
- N-(6-Chloro-3-formylpyridin-2-yl)pivalamide
- Packaging
- 500mg
- Price
- $365
- Updated
- 2021/12/16
- Product number
- HCH0369780
- Product name
- N-(6-CHLORO-3-FORMYLPYRIDIN-2-YL)PIVALAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.43
- Updated
- 2021/12/16
- Product number
- 119926
- Product name
- N-(6-Chloro-3-formylpyridin-2-yl)pivalamide
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $519
- Updated
- 2021/12/16
N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide Chemical Properties,Usage,Production
Synthesis
86847-84-9
68-12-2
127446-34-8
General procedure: synthesis of Intermediate 6: Intermediate 5 (19.28 g, 90.6 mmol) was dissolved in THF (181 mL), cooled to -20 °C, 77-BuLi (108.8 mL, 272 mmol) was slowly added, and the temperature was kept at -20 °C with stirring for 3 hours. Subsequently, DMF (20.81 mL, 271.86 mmol) was added dropwise to the reaction mixture and gradually warmed to room temperature. After completion of the reaction, the mixture was poured into pre-cooled 6N HCl and stirred for 15 min. It was neutralized with anhydrous K2CO3 to pH=7 and then extracted with Et2O. The organic layers were combined, washed sequentially with water and brine and dried over anhydrous Na2SO4. After concentration under reduced pressure, it was purified by recrystallization from a solvent mixture of EtOAc and hexane to afford N-(6-chloro-3-formylpyridin-2-yl)pivalamide (Intermediate 6) (12.84 g, 59% yield).
References
[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 16, p. 3134 - 3147
[2] Patent: WO2012/3418, 2012, A2. Location in patent: Page/Page column 47
[3] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 93; 94
[4] Journal of Organic Chemistry, 1990, vol. 55, # 15, p. 4744 - 4750
N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide Preparation Products And Raw materials
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