Lecozotan hydrochloride

Product Name: Lecozotan hydrochloride
CAS No.: 433282-68-9
Chemical Name: Lecozotan hydrochloride
Synonyms: Sra-333;Sra 333;Lecozotan sr;Lecozotan HCl;Lecozotan hydrochloride;Benzamide, 4-cyano-N-((2R)-2-(4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)propyl)-N-2-pyridinyl-, monohydrochloride;Benzamide, 4-cyano-N-[(2R)-2-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl]propyl]-N-2-pyridinyl-, hydrochloride (1:1)
CBNumber: CB92491997
Molecular Formula: C28H29N5O3.ClH
Formula Weight: 520.02
MOL File: 433282-68-9.mol

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Lecozotan hydrochloride Property

Melting point:: 239-240 °C

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Hazard and Precautionary Statements (GHS)

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Lecozotan hydrochloride Chemical Properties,Usage,Production

Description

Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. Chronic administration of Lecozotan HCl did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model demonstrating 5-HT(1A) receptor function.

Uses

Treatment of cognitive deficits associated with Alzheimer’s disease (5-HT1A receptor antagonist).

References

[1] WAYNE E. CHILDERS. Synthesis and Biological Evaluation of Benzodioxanylpiperazine Derivatives as Potent Serotonin 5-HT1A Antagonists: The Discovery of Lecozotan[J]. Journal of Medicinal Chemistry, 2005, 48 10: 3467-3470. DOI:10.1021/jm049493z.
[2] L E SCHECHTER. Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties.[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 314 3: 1274-1289. DOI:10.1124/jpet.105.086363.
[3] KEVIN BOOTH. P3-425: Safety, tolerability and efficacy of lecozotan SR in patients with mild-to-moderate Alzheimer’s disease used as monotherapy or adjunctively with a cholinesterase inhibitor[J]. Alzheimer’s & Dementia, 2012, 8 4S_Part_16: P604. DOI:10.1016/j.jalz.2012.05.2099.
[4] MIGUEL SKIRZEWSKI . Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behavioral depression[J]. Pharmacology Biochemistry and Behavior, 2010, 95 3: Pages 325-330. DOI:10.1016/j.pbb.2010.02.008.

Lecozotan hydrochloride Preparation Products And Raw materials

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Lecozotan hydrochloride Suppliers

CHINA 8 United States 1 Global 9

TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Sangon Biotech (Shanghai) Co.,Ltd.

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433282-68-9, Lecozotan hydrochlorideRelated Search:

Lecozotan

Benzamide, 4-cyano-N-((2R)-2-(4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)propyl)-N-2-pyridinyl-, monohydrochloride

Lecozotan HCl

Lecozotan hydrochloride

Lecozotan sr

Sra 333

Sra-333

Benzamide, 4-cyano-N-[(2R)-2-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl]propyl]-N-2-pyridinyl-, hydrochloride (1:1)

433282-68-9