ChemicalBook > CAS DataBase List > Gilenia

Gilenia

Product Name
Gilenia
CAS No.
162359-55-9
Chemical Name
Gilenia
Synonyms
Gilenia;Fingomod;Fingolise;fingolimo;fenogliMod;Fingolimod;FingoliMod-D4;FingoliMod Base;Gilenia USP/EP/BP;Fingolimod(FTY720)
CBNumber
CB92498299
Molecular Formula
C19H33NO2
Formula Weight
307.47
MOL File
162359-55-9.mol
More
Less

Gilenia Property

Melting point:
103-105°
Boiling point:
479.5±45.0 °C(Predicted)
Density 
1.016
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Chloroform (Very Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly,
pka
12.20±0.20(Predicted)
form 
Solid
color 
Off-White
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H402Harmful to aquatic life

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
11975
Product name
Fingolimod
Purity
≥98%
Packaging
5mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
11975
Product name
Fingolimod
Purity
≥98%
Packaging
10mg
Price
$105
Updated
2024/03/01
Cayman Chemical
Product number
11975
Product name
Fingolimod
Purity
≥98%
Packaging
25mg
Price
$241
Updated
2024/03/01
Cayman Chemical
Product number
11975
Product name
Fingolimod
Purity
≥98%
Packaging
50mg
Price
$429
Updated
2024/03/01
TRC
Product number
F342045
Product name
Fingolimod
Packaging
25mg
Price
$170
Updated
2021/12/16
More
Less

Gilenia Chemical Properties,Usage,Production

Chemical Properties

white solid

Uses

Prophylaxis of organ rejection in patients receiving allogenic renal transplants (sphingosine-1-phosphate receptor).

Uses

Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.

Definition

ChEBI: An aminodiol that consists of propane-1,3-diol having amino and 2-(4-octylphenyl)ethyl substituents at the 2-position. It is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. A prodrug, fingolimo is phosphorylated by sphingosine kinase to active metabolite fingolimod-phosphate, a structural analogue of sphingosine 1-phosphate.

Clinical Use

Sphingosine 1-phosphate receptor modulator:
Treatment of highly active relapsing-remitting multiple sclerosis

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: possible increased risk of bradycardia with amiodarone, disopyramide and dronedarone.
Antifungals: concentration increased by ketoconazole.
Beta-blockers: possibly increased risk of bradycardia.
Calcium channel blockers: possible increased risk of bradycardia with diltiazem and verapamil.

Metabolism

Transformed by reversible stereoselective phosphorylation to the pharmacologically active (S)-enantiomer of fingolimod phosphate. It is eliminated by oxidative biotransformation mainly via the cytochrome P450 4F2 isoenzyme and subsequent fatty acid-like degradation to inactive metabolites, and by formation of pharmacologically inactive non-polar ceramide analogues of fingolimod. The main enzyme involved in the metabolism of fingolimod is partially identified and may be either CYP4F2 or CYP3A4. 81% excreted as inactive metabolites in the urine and <2.5% in the faeces as metabolites and unchanged drug.

Gilenia Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Gilenia Suppliers

Australia 1 China 150 India 15 United Kingdom 1 United States 11 Global 178
Hefei HomeSunshine Pharmaceutical Technology Co., Ltd.
Tel
0551-65523315 17705606359
Fax
0551-65523375
Email
errol@homesunshinepharma.com
Country
China
ProdList
71
Advantage
58
Nanjing Chemipioneer Pharma& Tech Co., LTD
Tel
025-52643182 13914798241
Fax
025-52643182
Email
zhoulq@chemipioneer.com.cn
Country
China
ProdList
80
Advantage
62
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
sales@zhiwe.net
Country
China
ProdList
627
Advantage
61
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2988
Advantage
65
Suzhou Zehou Biotechnology Co. , Ltd.
Tel
0512-68716880 19984816880
Fax
18075373931
Email
sales@growingchem.com
Country
China
ProdList
194
Advantage
64
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19182
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8836
Advantage
52
Shanghai Everchem Co., Ltd
Tel
86-29-81325371
Fax
+86-29-81325373
Email
info@everchem.cn
Country
China
ProdList
84
Advantage
62
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3991
Advantage
60
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Shenzhen Nexconn Pharmatechs Ltd.
Tel
0755-89396905
Email
admin@nexconn.com
Country
China
ProdList
299
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Dongyang Honsen Co., Limited
Tel
+86-0579-86846643 18072368515
Fax
+86-0579-86846643
Email
sales@honsentech.com.cn
Country
China
ProdList
124
Advantage
55
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
Advantage
55
Shanghai eliv pharmaceutical Co.,Ltd.
Tel
021-50158063
Fax
021-6153 1846
Email
sales@elivpharma.com
Country
China
ProdList
646
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Shanghai Goyic Pharmaceutical & Chemical Co., Ltd.
Tel
021-50689757 15618953996
Fax
021-60275964
Email
sales@goyic.com
Country
China
ProdList
312
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.
Tel
027-65526929 15102793023
Fax
027-65526669
Email
hbhxry@foxmail.com
Country
China
ProdList
2006
Advantage
55
Hefei Hirisun Pharmatech Co., Ltd.
Tel
+86-0551-62678551 +86-15056975894
Fax
0551-62678551
Email
sales@hirisunpharm.com
Country
China
ProdList
181
Advantage
55
Chengdu Saiousi Pharmaceutical Co., Ltd
Tel
028-64971018 18108168130
Fax
86 028-64971018
Country
China
ProdList
1781
Advantage
55
Zhengzhou JACS Chemical Co., Ltd.
Tel
0371-0371-86259281 15981966935
Fax
0371-86259281
Email
jacschem@163.com
Country
China
ProdList
2003
Advantage
58
Shanghai YuMei Pharmaceutical Chemical Co., Ltd.
Tel
13661490451 13671802554
Fax
QQ627235036
Email
xyfn@163.com
Country
China
ProdList
582
Advantage
58
Aikon International Limited
Tel
025-66113011 18112977050
Fax
(5)02557626880
Email
cb6@aikonchem.com
Country
China
ProdList
15494
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Nanjing NingFan Pharm-Tech CO. LTD.
Tel
17368696818
Country
China
ProdList
1984
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Nanjing crow LuNing pharmaceutical technology co., LTD
Tel
13382066392
Country
CHINA
ProdList
4877
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Hubei Dibai Chemical Co., Ltd.
Tel
027-87058617 15872383390
Fax
027-87058617
Email
hbdibo@163.com
Country
China
ProdList
885
Advantage
58
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566 18001021521;
Fax
82387566-801
Email
sales@mreda.com.cn
Country
China
ProdList
10789
Advantage
58
More
Less

View Lastest Price from Gilenia manufacturers

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
Product
Gilenia 162359-55-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500MT/month
Release date
2022-01-19
Zhuozhou Wenxi import and Export Co., Ltd
Product
Gilenia 162359-55-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Gilenia 162359-55-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

162359-55-9, GileniaRelated Search:

Fingolimod EP Impurity D Fingolimod Palmitate Amide Fingolimod Impurity 4 Benzene, 1-(2-iodoethyl)-4-octyl- Fingolimod-d4 2-DiMethylaMino FingoliMod FTY720-d4 Hydrochloride diethyl 2-acetamido-2-(4-octylphenethyl)malonate 2-(4-OCTYLPHENYL)ETHANOL Fingolimod Fingolimod 2-Phenethyl Analog 2-NitrodeaMino FingoliMod 2-(Acetylamino)-2-[2-(4-octylphenyl)-2-oxoethyl]-propanedioic acid 1,3-diethyl ester N-(1-hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl)butan-2-yl)acetamide DIMETHYL 2-(HYDROXYIMINO)MALONATE Fingolimod 3-Phenethyl Analog Fingolimod Impurity 42 Fingolimod hydrochloride

  • 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol
  • Fingolimod(FTY720)
  • Gilenia
  • Fingolimod
  • 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propandiol
  • FingoliMod Base
  • fenogliMod
  • 1,3-Propanediol,2-aMino-2-[2-(4-octylphenyl)ethyl]-
  • Fingolise
  • FingoliMod-D4
  • Gilenia, Fingolimod
  • Gilenya(Fingolise)
  • 2-amino-2-(4-octylphenethyl)propane-1,3-diol
  • fingolimo
  • Gilenia USP/EP/BP
  • FingolimodQ: What is Fingolimod Q: What is the CAS Number of Fingolimod Q: What is the storage condition of Fingolimod Q: What are the applications of Fingolimod
  • Fingolimod (FTY720 free base)
  • Fingomod
  • 162359-55-9
  • pharmaceutical intermediate
  • API