2,6-Diethyl-4-methylbromobenzene
Uses- Product Name
- 2,6-Diethyl-4-methylbromobenzene
- CAS No.
- 314084-61-2
- Chemical Name
- 2,6-Diethyl-4-methylbromobenzene
- Synonyms
- 2-Bromo-1,3-diethyl-5-methylbenzene;2-Bromo-1,3-diethyl-5;4-Bromo-3,5-diethyltoluene;2,6-Diethyl-4-methylbromobenzene;2,6-Diethyl-4-methylphenyl bromide;2,6-Diethyl-4-methyl-1-bromobenzene;1-BroMo-2,6-diethyl-4-Methylbenzene;Benzene, 2-broMo-1,3-diethyl-5-Methyl-
- CBNumber
- CB92498714
- Molecular Formula
- C11H15Br
- Formula Weight
- 227.14
- MOL File
- 314084-61-2.mol
2,6-Diethyl-4-methylbromobenzene Property
- Boiling point:
- 259℃
- Density
- 1.211
- Flash point:
- 109℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Oil
- color
- Colourless to Dark Yellow
- InChI
- InChI=1S/C11H15Br/c1-4-9-6-8(3)7-10(5-2)11(9)12/h6-7H,4-5H2,1-3H3
- InChIKey
- QWIITRRSNVBPDK-UHFFFAOYSA-N
- SMILES
- C1(CC)=CC(C)=CC(CC)=C1Br
- EPA Substance Registry System
- Benzene, 2-bromo-1,3-diethyl-5-methyl- (314084-61-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B700500
- Product name
- 2-Bromo-1,3-diethyl-5-methylbenzene
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FB140033
- Product name
- 2-Bromo-1,3-diethyl-5-methylbenzene
- Packaging
- 2g
- Price
- $63
- Updated
- 2021/12/16
- Product number
- J56309
- Product name
- 2-Bromo-1,3-diethyl-5-methylbenzene
- Packaging
- 5g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- 119855
- Product name
- 2-Bromo-1,3-diethyl-5-methylbenzene
- Purity
- 95+%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- Z4585
- Product name
- 2-Bromo-1,3-diethyl-5-methylbenzene
- Packaging
- 10g
- Price
- $169
- Updated
- 2021/12/16
2,6-Diethyl-4-methylbromobenzene Chemical Properties,Usage,Production
Uses
2,6-Diethyl-4-methylbromobenzene is used as a pharmaceutical intermediate.
Chemical Properties
light yellow liquid
Synthesis
24544-08-9
314084-61-2
General procedure for the synthesis of 2-bromo-1,3-diethyl-5-methylbenzene from 2,6-diethyl-4-methylaniline: 5.2 g (0.4 mol) of 2,6-diethyl-4-methylaniline was dissolved in 280 g of hydrobromic acid (40% by mass) and cooled down to 0°C. Slowly, an aqueous sodium nitrite solution was added dropwise (prepared by dissolving 33.1 g of 0.48 mol sodium nitrite in 100 mL of water). dissolved in 100 mL of water), and after the dropwise addition, stirring was continued for 30 minutes. Subsequently, 26.2 g (0.2 mol) of cuprous bromide was added and the reaction mixture was heated to 60 °C and maintained at this temperature for 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was poured into 250 mL of ice water and extracted three times with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the solvent was evaporated to give 92.36 g of crude product. Fractions with boiling points of 102-106 °C/5 mmHg were collected by distillation under reduced pressure, resulting in 81.07 g of the target product 2-bromo-1,3-diethyl-5-methylbenzene in 89.2% yield.
References
[1] Patent: CN106928253, 2017, A. Location in patent: Paragraph 0039-0043
[2] Patent: WO2006/84663, 2006, A1. Location in patent: Page/Page column 11
[3] Patent: WO2006/84663, 2006, A1. Location in patent: Page/Page column 11
[4] Patent: US2010/234652, 2010, A1. Location in patent: Page/Page column 4-5
2,6-Diethyl-4-methylbromobenzene Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2,6-Diethyl-4-methylbromobenzene manufacturers
- Product
- 2,6-Diethyl-4-methylbromobenzene 314084-61-2
- Price
- US $80.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-27
- Product
- 2,6-Diethyl-4-methylbromobenzene 314084-61-2
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 98%min
- Supply Ability
- G/KG/T
- Release date
- 2019-12-23