ChemicalBook > CAS DataBase List > 1-(5-Bromo-2,4-difluoro-phenyl)-ethanone

1-(5-Bromo-2,4-difluoro-phenyl)-ethanone

Product Name
1-(5-Bromo-2,4-difluoro-phenyl)-ethanone
CAS No.
864773-64-8
Chemical Name
1-(5-Bromo-2,4-difluoro-phenyl)-ethanone
Synonyms
1-(5-Bromo-2,4-difluorophenyl);5-broMo-2,4-difluoroacetophenobe;5'-Bromo-2',4'-difluoroacetophenone;5'-Bromo-2',4'-difluoroacetophenone 98%;1-(5-Bromo-2,4-difluoro-phenyl)-ethanone;Ethanone, 1-(5-bromo-2,4-difluorophenyl)-;1-(5-Bromo-2,4-difluorophenyl)ethan-1-one
CBNumber
CB92499625
Molecular Formula
C8H5BrF2O
Formula Weight
235.03
MOL File
864773-64-8.mol
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1-(5-Bromo-2,4-difluoro-phenyl)-ethanone Property

Boiling point:
254.0±40.0 °C(Predicted)
Density 
1.614±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
crystalline solid
color 
White
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Safety

HS Code 
2914790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B997213
Product name
1-(5-Bromo-2,4-difluorophenyl)ethanone
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
2617-B-22
Product name
5'-Bromo-2',4'-difluoroacetophenone
Purity
98%
Packaging
5G
Price
$495
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0362010
Product name
1-(5-BROMO-2,4-DIFLUOROPHENYL)ETHANONE
Purity
95.00%
Packaging
5MG
Price
$504.22
Updated
2021/12/16
Matrix Scientific
Product number
075791
Product name
1-(5-Bromo-2,4-difluorophenyl)ethanone
Purity
95+%
Packaging
5g
Price
$510
Updated
2021/12/16
SynQuest Laboratories
Product number
2617-B-22
Product name
5'-Bromo-2',4'-difluoroacetophenone
Purity
98%
Packaging
10g
Price
$795
Updated
2021/12/16
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1-(5-Bromo-2,4-difluoro-phenyl)-ethanone Chemical Properties,Usage,Production

Uses

1-(5-Bromo-2,4-difluoro-phenyl)-ethanone is a white powder crystal used in pharmaceutical synthesis and experimental research.

Synthesis

348-57-2

75-36-5

864773-64-8

1. in a dry reaction flask, anhydrous AlCl3 (1040 g, 7878.7 mmol) was added to 1-bromo-2,4-difluorobenzene (600 g, 3108.9 mmol) and stirred at 60 °C for 10 min. 2. acetyl chloride (366 g, 4662.4 mmol) was added slowly dropwise to the above mixture, maintaining the temperature at 60 °C for 4 hours. 3. after the dropwise addition was completed, the reaction mixture was continued to be stirred at 60 °C for 6 hours. 4. the reaction mixture was cooled to -10 °C and ice (2450 g) was added slowly, this process was controlled to be completed within 1.5 hours. 5. 12N HCl (1500mL) was added and stirred for 1 hour at room temperature. 6. EtOAc (9000mL) was added for extraction, the organic layer was separated, washed with water, dried over anhydrous Na2SO4 and filtered. 7. The organic phase was concentrated under pressure and the resulting residue was purified by silica gel column chromatography (eluent: petroleum ether/EtOAc, 50/1) to afford the target product 1-(5-bromo-2,4-difluorophenyl)ethanone (300 g, 41% yield).

References

[1] Patent: WO2011/154374, 2011, A1. Location in patent: Page/Page column 26
[2] Patent: WO2012/62751, 2012, A1. Location in patent: Page/Page column 41-42
[3] Patent: US2013/252952, 2013, A1. Location in patent: Paragraph 0167; 0168
[4] Patent: US2004/220194, 2004, A1. Location in patent: Page 44; 45
[5] Patent: US2005/239795, 2005, A1. Location in patent: Page/Page column 36

1-(5-Bromo-2,4-difluoro-phenyl)-ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(5-Bromo-2,4-difluoro-phenyl)-ethanone manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
1-(5-Bromo-2,4-difluoro-phenyl)-ethanone 864773-64-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
Henan Fengda Chemical Co., Ltd
Product
5'-Bromo-2',4'-difluoroacetophenone 864773-64-8
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-31
Career Henan Chemical Co
Product
1-(5-Bromo-2,4-difluoro-phenyl)-ethanone 864773-64-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

864773-64-8, 1-(5-Bromo-2,4-difluoro-phenyl)-ethanoneRelated Search:


  • 1-(5-Bromo-2,4-difluoro-phenyl)-ethanone
  • 5'-Bromo-2',4'-difluoroacetophenone 98%
  • 1-(5-Bromo-2,4-difluorophenyl)ethan-1-one
  • 5-broMo-2,4-difluoroacetophenobe
  • 5'-Bromo-2',4'-difluoroacetophenone
  • Ethanone, 1-(5-bromo-2,4-difluorophenyl)-
  • 1-(5-Bromo-2,4-difluorophenyl)
  • 864773-64-8