AM 114

Product Name: AM 114
CAS No.: 856849-35-9
Chemical Name: AM 114
Synonyms: AM 114;Proteasome inhibitor IX;Proteasome inhibitor IX, 10 mM in DMSO;3,5-Bis-[benzylidene-4-boronicacid]-1-methylpiperidin-4-one;Boronic acid, B,B'-[(1-methyl-4-oxo-3,5-piperidinediylidene)bis(methylidyne-4,1-phenylene)]bis-;(((1-Methyl-4-oxopiperidine-3,5-diylidene)bis(methaneylylidene))bis(4,1-phenylene))diboronic acid;acid,AM-114,chymotrypsin-like,PS-IX,EGCG,20S,p53,inhibit,ubiquitinated,Proteasome,Proteasome inhibitor IX,cytotoxic,Chalcone,AM114,Inhibitor,boronic,Anticancer,AM 114
CBNumber: CB92502880
Molecular Formula: C20H21B2NO5
Formula Weight: 377.01
MOL File: 856849-35-9.mol

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AM 114 Property

Boiling point:: 695.4±65.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: insoluble in H2O; ≥16.65 mg/mL in DMSO; ≥4.11 mg/mL in EtOH with ultrasonic
form: solid
pka: 8.19±0.17(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2564
Product name: AM114
Purity: ≥97%(HPLC)
Packaging: 10
Price: $135
Updated: 2021/12/16

Tocris

Product number: 2564
Product name: AM114
Purity: ≥97%(HPLC)
Packaging: 50
Price: $495
Updated: 2021/12/16

TRC

Product number: A634663
Product name: AM114
Packaging: 5mg
Price: $385
Updated: 2021/12/16

TRC

Product number: A634663
Product name: AM114
Packaging: 1mg
Price: $95
Updated: 2021/12/16

ChemScene

Product number: CS-0028428
Product name: ProteasomeinhibitorIX
Purity: 98.53%
Packaging: 10mg
Price: $100
Updated: 2021/12/16

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AM 114 Chemical Properties,Usage,Production

Uses

AM 114 induces significant cytotoxic effect in cancer cells through the inhibition of the cellular proteasome and provide a rationale for the further development of this class of compounds as novel cancer chemotherapeutic agents.

Biological Activity

am 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20s proteasome, with a value of 50% inhibition concentration ic50 of approximately 1 μm, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins. am 114 also exerts anti-cancer activity against cancer cells, which potently inhibits the growth of human colon cancer hct116 cells with values of ic50 of 1.5 μm and 0.6 μm in mtt and colony formation assays respectively.achanta g, modzelewska a, feng l, khan sr, huang p. a boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome. mol pharmacol. 2006 jul;70(1):426-33. epub 2006 apr 24.

AM 114 Preparation Products And Raw materials

Raw materials

Preparation Products

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AM 114 Suppliers

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856849-35-9, AM 114Related Search:

AM 114

3,5-Bis-[benzylidene-4-boronicacid]-1-methylpiperidin-4-one

Boronic acid, B,B'-[(1-methyl-4-oxo-3,5-piperidinediylidene)bis(methylidyne-4,1-phenylene)]bis-

Proteasome inhibitor IX

acid,AM-114,chymotrypsin-like,PS-IX,EGCG,20S,p53,inhibit,ubiquitinated,Proteasome,Proteasome inhibitor IX,cytotoxic,Chalcone,AM114,Inhibitor,boronic,Anticancer,AM 114

(((1-Methyl-4-oxopiperidine-3,5-diylidene)bis(methaneylylidene))bis(4,1-phenylene))diboronic acid

Proteasome inhibitor IX, 10 mM in DMSO

856849-35-9

C20H21B2NO5

Inhibitor