Pifithrin-α, p-Nitro
- Product Name
- Pifithrin-α, p-Nitro
- CAS No.
- 389850-21-9
- Chemical Name
- Pifithrin-α, p-Nitro
- Synonyms
- p-nitro-Pifithrin-α;p-nitro-Pifithrin-α;Pifithrin-α, p-Nitro;Pifithrin-α, p-Nitro;p-nitro-Pifithrin-.alpha.;Pifithrin-alpha, p-Nitro hydrobromide,;2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-nitrophenyl)ethanone;2-(2-IMINO-4,5,6,7-TETRAHYDROBENZO[D]THIAZOL-3(2H)-YL)-1-(4-NITROPHENYL)ETHANONE HBR
- CBNumber
- CB92503236
- Molecular Formula
- C15H16BrN3O3S
- Formula Weight
- 398.27484
- MOL File
- 389850-21-9.mol
Pifithrin-α, p-Nitro Property
- Melting point:
- 239-240 °C(Solv: methanol (67-56-1); ethyl acetate (141-78-6))
- storage temp.
- Store at -20°C, protect from light
- solubility
- Soluble in DMSO or ethanol
- form
- Solid
- color
- White to light yellow
- Sensitive
- Light Sensitive & Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- J64277
- Product name
- Pifithrin-alpha, p-Nitro hydrobromide
- Packaging
- 5mg
- Price
- $94.65
- Updated
- 2024/03/01
- Product number
- 16209
- Product name
- p-nitro-Pifithrin-α
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 16209
- Product name
- p-nitro-Pifithrin-α
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 16209
- Product name
- p-nitro-Pifithrin-α
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 16209
- Product name
- p-nitro-Pifithrin-α
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $479
- Updated
- 2024/03/01
Pifithrin-α, p-Nitro Chemical Properties,Usage,Production
Uses
A cell-permeable p53 inhibitor
Biological Activity
p-nitro-pifithrin-α, a cell-permeable cyclic analog of pifithrin-α, is an inhibitor of p53 activity [1].the p53 tumor suppressor gene product can induce apoptotic cell death and plays a dominant role in apoptosis, genomic stability, and inhibition of angiogenesis. the p53 has been considered to be an oncogene and the wild-type gene product actually functions as a tumour suppressor gene. p53 mutations play an important role in the development of many common human malignancies [2].in human proximal tubular cells, p-nitro-pifithrin-α (10 μm) suppressed p53-mediated tgf-β1 expression [3].
in vitro
in p53-/- cortical neuron, p-nitro-pifithrin-α exihibited a p53 inhibitory activity in preventing p53-induced death[1]. p-nitro-pifithrin-α did not prevent cortical neuronal death induced by p40met, showing the remarkable specificity in the inhibitory action of p-nitro-pifithrin-α on p53. p-nitro-pifithrin-α (300 nm) prevented p53-triggered increase in protein levels of p21/waf1, indicating that p-nitro-pifithrin-α behaved as p53 posttranscriptional activity inhibitors. p-nitro-pifithrin-α at a dose of 30 nm was sufficient to prevent the increase of p21/waf1 levels [1]. p-nitro-pifithrin-α was slowly converted into a more potent cyclized form, p-nitro cyclic pifithrin-α, when incubated in biological media (t1/2= 8 h)
in vivo
in a mouse model of non-alcoholic fatty liver disease, p-nitro-pifithrin-α attenuated steatosis and liver injury in mice fed a high-fat diet [4].
References
[1] pietrancosta n, moumen a, dono r, et al. imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism[j]. journal of medicinal chemistry, 2006, 49(12): 3645-3652.
[2] nigro j m, baker s j, preisinger a c, et al. mutations in the p53 gene occur in diverse human tumour types[j]. nature, 1989, 342(6250): 705-708.
[3] shimizu h, yisireyili m, nishijima f, et al. indoxyl sulfate enhances p53-tgf-β1-smad3 pathway in proximal tubular cells[j]. american journal of nephrology, 2013, 37(2): 97-103.
[4] derdak z, villegas k a, harb r, et al. inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease[j]. journal of hepatology, 2013, 58(4): 785-791.
Pifithrin-α, p-Nitro Preparation Products And Raw materials
Raw materials
Preparation Products
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