N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride

Product Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride
CAS No.: 478149-53-0
Chemical Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride
Synonyms: PHA-543613;PHA-543613 >=98% (HPLC);PHA 543613 hydrochloride;PHA 543613, 10 mM in DMSO;PHA-543,613 - CAS 478149-53-0 - Calbiochem;(R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carboxaMide;N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide;Furo[2,3-c]pyridine-5-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-;N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide;N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamidehydrochloride
CBNumber: CB92503302
Molecular Formula: C15H17N3O2
Formula Weight: 271.31
MOL File: 478149-53-0.mol

More

Less

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Property

Melting point:: 313-315 °C
Boiling point:: 508.0±40.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: DMSO: ≥20mg/mL
form: White powder
pka: 12.19±0.20(Predicted)
color: white to off-white

More

Less

Safety

WGK Germany: 1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0135
Product name: PHA-543613
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $159
Updated: 2025/07/31

Sigma-Aldrich

Product number: PZ0135
Product name: PHA-543613
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $594
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.05316
Product name: PHA-543,613 - CAS 478149-53-0 - Calbiochem
Packaging: 5MG
Price: $179
Updated: 2022/05/15

Tocris

Product number: 3092
Product name: PHA543613hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $223
Updated: 2021/12/16

ApexBio Technology

Product number: B5373
Product name: PHA543613hydrochloride
Packaging: 10mg
Price: $332
Updated: 2021/12/16

More

Less

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Chemical Properties,Usage,Production

Uses

PHA-543613 has been used to study its effect on recognition memory and neurovascular coupling (NVC) response in β-amyloid (Aβ) 25-35-treated mice. It has also been used to study its effect on Aβ25-35-induced receptor alteration and cognitive impairment in mice.

Definition

ChEBI: Pha-543613 is a phosphoramide and an organothiophosphorus compound.

Biological Activity

Primary Target
α7 nAChR

in vivo

PHA-543613 (0.3 mg/kg) successfully reverses Scopolamine-induced short-term memory deficits in rats^[2].? PHA-543613 (4 and 12 mg/kg; i.p. once) reduces behavioral deficits and brain edema^[3].

Animal Model:	Male CD-1 mice with (intracerebral hemorrhage) ICH-induction or sham surgery^[3]
Dosage:	4 and 12 mg/kg
Administration:	Intraperitoneal injection; 4 and 12 mg/kg; 1 hour after surgery
Result:	Increased p-Akt and decreased p-GSK-3 and CC3 expressions in the ipsilateral hemisphere and reduced the neuronal cell death in the perihematomal area. Attenuated behavioral deficits and brain edema at 72 hours after ICH.

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Suppliers

China 27 United Kingdom 1 United States 4 Global 32

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3932
Advantage: 58

Hunan Huayi Zhide Pharmaceutical Technology Co., Ltd.

Tel: 17752881701
Email: 190060276@qq.com
Country: China
ProdList: 170
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Hangzhou FuRun Pharmaceutical Technology Co., Ltd

Tel: 15658004993
Email: 1900830611@qq.com
Country: China
ProdList: 980
Advantage: 58

NewCan Biotech Limited

Tel: +86-0571-86912261 +86-15658003402
Fax: 311113
Email: sales@newcanbio.com
Country: China
ProdList: 1391
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Suzhou Meishi Biotechnology Co., Ltd.

Tel: 1173954148q
Email: meishipharma@126.com
Country: China
ProdList: 20033
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.

Tel: 025-66061636 18013972705
Email: qqyang@aikonchem.com
Country: China
ProdList: 10151
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Guangzhou Baide Biotechnology Co., Ltd.

Tel: 18925065404
Country: CHINA
ProdList: 168
Advantage: 58

Guangzhou Yansai Biological Products Co., Ltd.

Tel: 13710209565
Country: CHINA
ProdList: 122
Advantage: 58

Guangzhou Taozhu Biotechnology Co., Ltd

Tel: 4008200310
Country: CHINA
ProdList: 111
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6482
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

478149-53-0, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochlorideRelated Search:

PHA-543,613 - CAS 478149-53-0 - Calbiochem

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamidehydrochloride

PHA 543613 hydrochloride

PHA-543613

(R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carboxaMide

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxaMide hydrochlorid

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide

N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride

Furo[2,3-c]pyridine-5-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-

PHA-543613 >=98% (HPLC)

PHA 543613, 10 mM in DMSO

478149-53-0

C15H17N3O22HCl