6-bromo-5-chloro-indole
- Product Name
- 6-bromo-5-chloro-indole
- CAS No.
- 1191028-50-8
- Chemical Name
- 6-bromo-5-chloro-indole
- Synonyms
- 6-bromo-5-chloro-indole;1H-Indole, 6-broMo-5-chloro-
- CBNumber
- CB92504738
- Molecular Formula
- C8H5BrClN
- Formula Weight
- 230.49
- MOL File
- 1191028-50-8.mol
6-bromo-5-chloro-indole Property
- Density
- 1.772
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light brown to brown Solid
N-Bromosuccinimide Price
- Product number
- B701858
- Product name
- 6-Bromo-5-chloro-1H-indole
- Packaging
- 500mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 3H31-D-22
- Product name
- 6-Bromo-5-chloro-1H-indole
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- 089755
- Product name
- 6-Bromo-5-chloro-1H-indole
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $492
- Updated
- 2021/12/16
- Product number
- HCH0048060
- Product name
- 6-BROMO-5-CHLORO-1H-INDOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.34
- Updated
- 2021/12/16
- Product number
- 3H31-D-22
- Product name
- 6-Bromo-5-chloro-1H-indole
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $790
- Updated
- 2021/12/16
6-bromo-5-chloro-indole Chemical Properties,Usage,Production
Synthesis
16588-26-4
1826-67-1
1191028-50-8
1191028-48-4
A tetrahydrofuran (THF) solution of 1.0 M vinylmagnesium bromide (0.13 L, 130 mmol) was slowly added dropwise to a 140 mL THF solution of 10 g (43 mmol) of 3-bromo-4-chloronitrobenzene at -40 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at -40 °C for 1 hour. Subsequently, the reaction mixture was slowly warmed to room temperature and extracted with ethyl acetate (EtOAc). The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO?), filtered and concentrated. The crude product was purified twice by column chromatography (eluent: hexane solution of 33% ethyl acetate) to give 0.95 g (9.7% yield) of 4-bromo-5-chloro-1H-indole and 0.77 g (7.9% yield) of 6-bromo-5-chloro-1H-indole, respectively. Each indole product was dissolved in acetonitrile (MeCN) and the reaction was carried out by adding 1.1 equiv. of di-tert-butyl dicarbonate (Boc?O) and 0.2 equiv. of 4-dimethylaminopyridine (DMAP). Upon completion of the reaction, the mixture was concentrated and the residue was purified by column chromatography (eluent: 10% hexane solution of ethyl acetate) to give 1-011 (32% yield) and 1-012 (48% yield).
References
[1] Patent: WO2009/126675, 2009, A1. Location in patent: Page/Page column 125
6-bromo-5-chloro-indole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-bromo-5-chloro-indole manufacturers
- Product
- 6-bromo-5-chloro-indole 1191028-50-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19