2-bromo-1-(1-Boc-piperidin-4-yl)ethanone
Application- Product Name
- 2-bromo-1-(1-Boc-piperidin-4-yl)ethanone
- CAS No.
- 301221-79-4
- Chemical Name
- 2-bromo-1-(1-Boc-piperidin-4-yl)ethanone
- Synonyms
- tert-Butyl 4-(2-bromoacetyl);1-Boc-4-(2-broMo-acetyl)-piperidine;2-bromo-1-(1-Boc-piperidin-4-yl)ethanone;4-(2-bromoacetyl)piperidine-1-carboxylate;4-BroMoacetyl-1-(t-butoxycarbonyl)piperidine;tert-Butyl 4-(bromoacetyl)piperidine-1-carboxylate;4-(2-BroMo-acetyl)-piperidine-1-carboxylic acid tert-butyl ester;4-(2-Bromoacetyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;1-Piperidinecarboxylic acid, 4-(2-bromoacetyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB92504743
- Molecular Formula
- C12H20BrNO3
- Formula Weight
- 306.2
- MOL File
- 301221-79-4.mol
2-bromo-1-(1-Boc-piperidin-4-yl)ethanone Property
- Boiling point:
- 368℃
- Density
- 1.336
- Flash point:
- 176℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.47±0.40(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C12H20BrNO3/c1-12(2,3)17-11(16)14-6-4-9(5-7-14)10(15)8-13/h9H,4-8H2,1-3H3
- InChIKey
- HYRSGTXIVIMOOX-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(C(CBr)=O)CC1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- D6185
- Product name
- tert-Butyl 4-(2-Bromoacetyl)piperidine-1-carboxylate
- Purity
- min. 95.0 %
- Packaging
- 1G
- Price
- $147
- Updated
- 2025/07/31
- Product number
- D6185
- Product name
- tert-Butyl 4-(2-Bromoacetyl)piperidine-1-carboxylate
- Purity
- min. 95.0 %
- Packaging
- 5G
- Price
- $441
- Updated
- 2025/07/31
- Product number
- B695370
- Product name
- tert-Butyl4-(2-Bromoacetyl)piperidine-1-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 069131
- Product name
- tert-Butyl 4-(2-bromoacetyl)-piperidine-1-carboxylate
- Purity
- >95%
- Packaging
- 250mg
- Price
- $34
- Updated
- 2021/12/16
- Product number
- 069131
- Product name
- tert-Butyl 4-(2-bromoacetyl)-piperidine-1-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
2-bromo-1-(1-Boc-piperidin-4-yl)ethanone Chemical Properties,Usage,Production
Application
4-(bromoacetyl)piperidine-1-carboxylic acid tert-butyl ester is an ester organic compound that can be used to prepare drugs for treating Huntington's disease.
Synthesis
206989-61-9
301221-79-4
The general procedure for the synthesis of N-Boc-4-(bromoacetyl)piperidine from 1-N-BOC-4-acetylpiperidine was as follows: to a suspension of tert-butyl 4-ethylpiperidine-1-carboxylate (Intermediate B5; 2.87 g, 12.6 mmol) in THF (30 mL) cooled to -78 °C, a THF solution of 1 M bis(trimethylmethylsilyl)lithium amide was slowly added (13.3 mL), and the addition time was controlled within 20 min. The reaction mixture was stirred at -78 °C for 1 h. Trimethylsilyl chloride (1.74 mL, 13.7 mmol) was added. Stirring was continued at 0 °C for 30 min, after which the reaction solution was cooled again to -78 °C and bromine (0.645 mL, 12.6 mmol) was added slowly. After the reaction mixture was naturally warmed to room temperature, the reaction was quenched by pouring into a mixture of 10% Na2S2O3 solution (20 mL) and saturated NH4Cl solution (20 mL). The organic phase was extracted with EtOAc (2×80 mL) and the organic layers were combined, which were treated to afford the target product N-Boc-4-(bromoacetyl)piperidine in a yield of 3.69 g in 96%.
References
[1] Patent: WO2009/150144, 2009, A1. Location in patent: Page/Page column 139
[2] Tetrahedron Letters, 2012, vol. 53, # 7, p. 852 - 853
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 13, p. 3419 - 3424
[4] Patent: WO2004/41279, 2004, A1. Location in patent: Page/Page column 70
[5] Patent: WO2015/88565, 2015, A1. Location in patent: Paragraph 00214
2-bromo-1-(1-Boc-piperidin-4-yl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-bromo-1-(1-Boc-piperidin-4-yl)ethanone manufacturers
- Product
- 2-Bromo-1-(1-Boc-piperidin-4-yl)ethanone 301221-79-4
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 2-bromo-1-(1-Boc-piperidin-4-yl)ethanone 301221-79-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-30