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ChemicalBook > CAS DataBase List > 2-bromo-1-(1-Boc-piperidin-4-yl)ethanone

2-bromo-1-(1-Boc-piperidin-4-yl)ethanone

Application
Product Name
2-bromo-1-(1-Boc-piperidin-4-yl)ethanone
CAS No.
301221-79-4
Chemical Name
2-bromo-1-(1-Boc-piperidin-4-yl)ethanone
Synonyms
tert-Butyl 4-(2-bromoacetyl);1-Boc-4-(2-broMo-acetyl)-piperidine;2-bromo-1-(1-Boc-piperidin-4-yl)ethanone;4-(2-bromoacetyl)piperidine-1-carboxylate;4-BroMoacetyl-1-(t-butoxycarbonyl)piperidine;tert-Butyl 4-(bromoacetyl)piperidine-1-carboxylate;4-(2-BroMo-acetyl)-piperidine-1-carboxylic acid tert-butyl ester;4-(2-Bromoacetyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;1-Piperidinecarboxylic acid, 4-(2-bromoacetyl)-, 1,1-dimethylethyl ester
CBNumber
CB92504743
Molecular Formula
C12H20BrNO3
Formula Weight
306.2
MOL File
301221-79-4.mol
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2-bromo-1-(1-Boc-piperidin-4-yl)ethanone Property

Boiling point:
368℃
Density 
1.336
Flash point:
176℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-2.47±0.40(Predicted)
Appearance
Off-white to yellow Solid
InChI
InChI=1S/C12H20BrNO3/c1-12(2,3)17-11(16)14-6-4-9(5-7-14)10(15)8-13/h9H,4-8H2,1-3H3
InChIKey
HYRSGTXIVIMOOX-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(C(CBr)=O)CC1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D6185
Product name
tert-Butyl 4-(2-Bromoacetyl)piperidine-1-carboxylate
Purity
min. 95.0 %
Packaging
1G
Price
$147
Updated
2025/07/31
TCI Chemical
Product number
D6185
Product name
tert-Butyl 4-(2-Bromoacetyl)piperidine-1-carboxylate
Purity
min. 95.0 %
Packaging
5G
Price
$441
Updated
2025/07/31
TRC
Product number
B695370
Product name
tert-Butyl4-(2-Bromoacetyl)piperidine-1-carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
069131
Product name
tert-Butyl 4-(2-bromoacetyl)-piperidine-1-carboxylate
Purity
>95%
Packaging
250mg
Price
$34
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-9-3H
Product name
tert-Butyl 4-(2-bromoacetyl)piperidine-1-carboxylate
Purity
97.0%
Packaging
250mg
Price
$490
Updated
2021/12/16
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2-bromo-1-(1-Boc-piperidin-4-yl)ethanone Chemical Properties,Usage,Production

Application

4-(bromoacetyl)piperidine-1-carboxylic acid tert-butyl ester is an ester organic compound that can be used to prepare drugs for treating Huntington's disease.

Synthesis

206989-61-9

301221-79-4

The general procedure for the synthesis of N-Boc-4-(bromoacetyl)piperidine from 1-N-BOC-4-acetylpiperidine was as follows: to a suspension of tert-butyl 4-ethylpiperidine-1-carboxylate (Intermediate B5; 2.87 g, 12.6 mmol) in THF (30 mL) cooled to -78 °C, a THF solution of 1 M bis(trimethylmethylsilyl)lithium amide was slowly added (13.3 mL), and the addition time was controlled within 20 min. The reaction mixture was stirred at -78 °C for 1 h. Trimethylsilyl chloride (1.74 mL, 13.7 mmol) was added. Stirring was continued at 0 °C for 30 min, after which the reaction solution was cooled again to -78 °C and bromine (0.645 mL, 12.6 mmol) was added slowly. After the reaction mixture was naturally warmed to room temperature, the reaction was quenched by pouring into a mixture of 10% Na2S2O3 solution (20 mL) and saturated NH4Cl solution (20 mL). The organic phase was extracted with EtOAc (2×80 mL) and the organic layers were combined, which were treated to afford the target product N-Boc-4-(bromoacetyl)piperidine in a yield of 3.69 g in 96%.

References

[1] Patent: WO2009/150144, 2009, A1. Location in patent: Page/Page column 139
[2] Tetrahedron Letters, 2012, vol. 53, # 7, p. 852 - 853
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 13, p. 3419 - 3424
[4] Patent: WO2004/41279, 2004, A1. Location in patent: Page/Page column 70
[5] Patent: WO2015/88565, 2015, A1. Location in patent: Paragraph 00214

2-bromo-1-(1-Boc-piperidin-4-yl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-bromo-1-(1-Boc-piperidin-4-yl)ethanone Suppliers

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View Lastest Price from 2-bromo-1-(1-Boc-piperidin-4-yl)ethanone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Bromo-1-(1-Boc-piperidin-4-yl)ethanone 301221-79-4
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Career Henan Chemical Co
Product
2-bromo-1-(1-Boc-piperidin-4-yl)ethanone 301221-79-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-30

301221-79-4, 2-bromo-1-(1-Boc-piperidin-4-yl)ethanoneRelated Search:

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  • 4-(2-BroMo-acetyl)-piperidine-1-carboxylic acid tert-butyl ester
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  • 4-(2-bromoacetyl)piperidine-1-carboxylate
  • 301221-79-4