ChemicalBook > CAS DataBase List > N-Tosyl-L-alanine
N-Tosyl-L-alanine
- Product Name
- N-Tosyl-L-alanine
- CAS No.
- 21957-58-4
- Chemical Name
- N-Tosyl-L-alanine
- Synonyms
- N-Tosyl-L-Ala;Tos-Ala-OH,97%;N-Tosyl-L-alanine USP/EP/BP;N-(Toluene-4-sulfonyl)-L-alanine;N-[(4-Methylphenyl)sulfonyl]-L-alanine;L-Alanine,N-[(4-methylphenyl)sulfonyl]-;(S)-2-(4-MethylphenylsulfonaMido)propanoic acid;(2S)-2-(4-methylbenzenesulfonamido)propanoic acid;(2S)-2-[(4-methylphenyl)sulfonylamino]propanoicaci;(2S)-2-[[(4-Methylphenyl)sulfonyl]aMino]propanoic Acid
- CBNumber
- CB92505694
- Molecular Formula
- C10H13NO4S
- Formula Weight
- 243.28
- MOL File
- 21957-58-4.mol
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N-Tosyl-L-alanine Property
- Melting point:
- 138-139℃
- Boiling point:
- 428.9±55.0 °C(Predicted)
- Density
- 1.319
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Chloroform, Methanol
- form
- Solid
- pka
- 3.45±0.10(Predicted)
- color
- White
- optical activity
- Consistent with structure
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- CDS004033
- Product name
- Tos-Ala-OH
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $73.1
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M3484
- Product name
- Tos-Ala-OH
- Packaging
- 5G
- Price
- $40
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M3484
- Product name
- Tos-Ala-OH
- Packaging
- 25G
- Price
- $119
- Updated
- 2025/07/31
TRC
- Product number
- T550525
- Product name
- N-Tosyl-L-alanine
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
Ark Pharm
- Product number
- AK119825
- Product name
- (S)-2-(4-Methylphenylsulfonamido)propanoicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $11
- Updated
- 2021/12/16
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N-Tosyl-L-alanine Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
N-Tosyl-L-alanine (cas# 21957-58-4) is a compound useful in organic synthesis.
reaction suitability
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis
Synthesis
56-41-7
98-59-9
4816-81-3
GENERAL STEPS: The synthesis was carried out using the N-toluene sulfonylation method reported in the literature. In a round-bottomed flask, 2.4 equivalents of Na2CO3 was dissolved in water at 70 °C (concentration 0.66 mol/L). Subsequently, 1.0 equiv. of L-alanine was added, followed by the slow addition of 1.4 equiv. of p-toluenesulfonyl chloride. The resulting suspension was stirred and reacted at 70 °C for 40 min, followed by warming to 85 °C and continued stirring for 5 min. Upon completion of the reaction, the reaction mixture was filtered directly and the solids were washed with hot water at 85°C. The filtrate was cooled to room temperature and acidified with 6 M aqueous HCl to pH=1. The precipitated solid product was collected by filtration and dried under vacuum. The resulting 2-(4-methylphenylsulfonamido)propionic acid was used for subsequent experiments without further purification.
References
[1] RSC Advances, 2015, vol. 5, # 24, p. 18751 - 18760
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 29, p. 4006 - 4012
[3] Organic and Biomolecular Chemistry, 2013, vol. 11, # 21, p. 3451 - 3460
[4] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2000, vol. 55, # 2, p. 203 - 207
[5] Journal of Organic Chemistry, 2003, vol. 68, # 17, p. 6632 - 6638
N-Tosyl-L-alanine Preparation Products And Raw materials
Raw materials
Preparation Products
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