ChemicalBook > CAS DataBase List > (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate

Product Name
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
CAS No.
179386-44-8
Chemical Name
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
Synonyms
CS-414;U95666E;PNU 95666;PNU 95666E;PNU-95,666 maleate;Sumanirole maleate;PubChem ID: 9818478;CID 9818479 maleate;U 95666E(Sumanirole maleate);Sumanirole maleate >=98% (HPLC)
CBNumber
CB92510117
Molecular Formula
C15H17N3O5
Formula Weight
319.32
MOL File
179386-44-8.mol
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(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Property

Melting point:
200-208°C (dec.)
storage temp. 
-20°C
solubility 
H2O: soluble10mg/mL, clear
form 
powder
color 
white to beige
optical activity
[α]/D -22 to -32°, c = 1 in H2O
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1087
Product name
Sumanirole maleate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$115
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1087
Product name
Sumanirole maleate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$184.8
Updated
2024/03/01
Sigma-Aldrich
Product number
5.05896
Product name
Sumanirole Maleate - CAS 179386-44-8 - Calbiochem
Packaging
5mg
Price
$191
Updated
2024/03/01
Cayman Chemical
Product number
11984
Product name
Sumanirole (maleate)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
11984
Product name
Sumanirole (maleate)
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
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(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Chemical Properties,Usage,Production

Uses

Sumanirole is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Sumanirole displays >200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). Sumanirole exhibits antiParkinsonian activity similar to Ropinirole (R641000).

Biochem/physiol Actions

Sumanirole is a highly selective and potent dopamine D2 receptor agonist that decreased plasma prolactin levels and depressed dopamine neuron firing rates in the substantia nigra pars compacta. Sumanirole potently stimulates locomotor activity in in animal models of Parkinson′s disease.

storage

Store at -20°C

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Suppliers

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179386-44-8, (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioateRelated Search:


  • (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
  • PNU 95666
  • Sumanirole maleate
  • U 95666E(Sumanirole maleate)
  • U95666E
  • PNU 95666E
  • (5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate
  • (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate
  • CID 9818479 maleate
  • PNU-95,666 maleate
  • PubChem ID: 9818478
  • (5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-butenedioate (1:1)
  • CS-414
  • U95666E;PNU 95666;PNU 95666E;SUMANIROLE
  • Sumanirole maleate >=98% (HPLC)
  • 179386-44-8
  • C11H13N3OC4H4O4