2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester
- Product Name
- 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester
- CAS No.
- 947249-01-6
- Chemical Name
- 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester
- Synonyms
- 2-Ami-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester;2-Amino-3-(trifluoromethyl) pyridine-5-boronic acid pinacol ...;2-Amino-3-(trifluoromethyl)-pyridine-5-boronic acid picol ester;6-Amino-5-(trifluoromethyl)pyridine-3-boronic acid pinacol ester;2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester;(6-AMINO-5-(TRIFLUOROMETHYL)PYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-amine;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-trifluoromethyl)pyridin-2-amine;3-(trifluoroMethyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-aMine;2-Pyridinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)-
- CBNumber
- CB92514832
- Molecular Formula
- C12H16BF3N2O2
- Formula Weight
- 288.07
- MOL File
- 947249-01-6.mol
2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester Property
- Melting point:
- 132-134℃
- Boiling point:
- 359.1±42.0 °C(Predicted)
- Density
- 1.23
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 4.31±0.50(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A633325
- Product name
- 2-Amino-3-(trifluoromethyl)pyridine-5-boronicacidpinacolester
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FA75169
- Product name
- 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- PC412228
- Product name
- 2-Amino-3-(trifluoromethyl)pyridine-5-boronicacid,pinacolester
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $63
- Updated
- 2021/12/16
- Product number
- FA75169
- Product name
- 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester
- Packaging
- 100mg
- Price
- $88
- Updated
- 2021/12/16
- Product number
- Z5387
- Product name
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-amine
- Packaging
- 250mg
- Price
- $143
- Updated
- 2021/12/16
2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester Chemical Properties,Usage,Production
Synthesis
79456-34-1
73183-34-3
947249-01-6
GENERAL STEPS: 5-bromo-3-(trifluoromethyl)pyridin-2-amine (180 g) was mixed with 1,4-dioxane (3600 mL) in a flask and stirred. Bis(pinacolato)diboron (284.47 g), potassium acetate (109.95 g) and 1,1'-bis(diphenylphosphino)ferrocene palladium(II) dichloride dichloromethane complex (18 g) were added sequentially at 25-30 °C. The reaction mixture was heated to 95-100 °C and maintained for 15-16 hours. After completion of the reaction, it was cooled to 25-30 °C, filtered through a bed of diatomaceous earth and the filter bed was washed with ethyl acetate (1800 mL). The filtrate was concentrated under reduced pressure to give the crude product 2-amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester (450 g). Purification step: the crude product was dissolved in methanol (1800 mL), activated carbon (45 g) and silica gel (60-120 mesh, 450 g) were added, and stirred at 25-30 °C for 1 hour. The mixture was filtered through a bed of diatomaceous earth and washed with methanol (450 mL). The filtrate was slowly added to cold water (6750 mL) over a period of 1 hour, maintaining the temperature at 0-5 °C. The precipitate was collected by filtration and washed with cold water (900 mL). The wet solid was dried at 45-50 °C to give purified 2-amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester (209 g). Yield: 97.47%. Purity: 98.43%. 1H NMR (300 MHz, DMSO-d6): δ 8.38 (s, 1H), 7.80 (s, 1H), 6.92 (s, 2H), 1.27 (s, 12H). MS: m/z 289.1 (M + 1)
References
[1] Patent: WO2015/145369, 2015, A1. Location in patent: Page/Page column 37
[2] Patent: WO2012/34526, 2012, A1. Location in patent: Page/Page column 36-37
[3] Patent: US2013/190307, 2013, A1. Location in patent: Paragraph 0172; 0173
[4] Patent: WO2010/8847, 2010, A2. Location in patent: Page/Page column 147-148
[5] Patent: WO2008/12326, 2008, A1. Location in patent: Page/Page column 69
2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester manufacturers
- Product
- 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester 947249-01-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester 947249-01-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-amine 947249-01-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- Min98%
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-10