Methyl N-Boc-4-hydroxypiperidine-3-carboxylate

Product Name: Methyl N-Boc-4-hydroxypiperidine-3-carboxylate
CAS No.: 406212-51-9
Chemical Name: Methyl N-Boc-4-hydroxypiperidine-3-carboxylate
Synonyms: Methyl N-Boc-4-hydroxypiperidine-3-;Methyl N-Boc-4-hydroxypiperidine-3-carboxylate;1-tert-butyl 3-Methyl 4-hydroxypiperidine-1,3-dicarboxylate;1-tert-Butyl 3-Methyl 4-hydroxy-1,3-piperidinedicarboxylate;Methyl N-(tert-Butoxycarbonyl)-4-hydroxypiperidine-3-carboxylate;4-Hydroxy-1,3-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-methyl ester;1,3-Piperidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 3-Methyl ester
CBNumber: CB92516124
Molecular Formula: C12H21NO5
Formula Weight: 259.3
MOL File: 406212-51-9.mol

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Methyl N-Boc-4-hydroxypiperidine-3-carboxylate Property

Boiling point:: 352.1±42.0 °C(Predicted)
Density: 1.182±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.12±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M338933
Product name: Methyln-boc-4-hydroxypiperidine-3-carboxylate
Packaging: 500mg
Price: $115
Updated: 2021/12/16

AK Scientific

Product number: V5805
Product name: Methyln-boc-4-hydroxypiperidine-3-carboxylate
Packaging: 1g
Price: $144
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0393414
Product name: METHYL-N-BOC-4-HYDROXYPIPERIDINE-3-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $505.82
Updated: 2021/12/16

Activate Scientific

Product number: AS3832
Product name: MethylN-Boc-4-hydroxypiperidine-3-carboxylate
Purity: 95+%
Packaging: 25g
Price: $1121
Updated: 2021/12/16

Labseeker

Product number: SC-47942
Product name: 1-tert-butyl3-methyl4-hydroxy-1,3-piperidinedicarboxyla
Purity: 95
Packaging: 250g
Price: $2255
Updated: 2021/12/16

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Methyl N-Boc-4-hydroxypiperidine-3-carboxylate Chemical Properties,Usage,Production

Synthesis

161491-24-3

406212-51-9

General procedure for the synthesis of methyl N-Boc-4-hydroxypiperidine-3-carboxylate from tert-butyl 4-oxopiperidine-1-carboxylate-3-carboxylate: To a solution of tert-butyl 1-(1,3-piperidinedicarboxylate) in methanol (800 mL) of 3-oxo-1,3-piperidinedicarboxylic acid (134.0 g, 520.8 mmol) was added in batches at 0 °C NaBH4 (9.85 g, 260.4 mmol). The reaction mixture was stirred overnight and allowed to warm up naturally to room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate, washed with saturated brine, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to afford 3-tert-butyl 3-methyl-4-hydroxy-1,3-piperidinedicarboxylate (120.8 g, 90% yield), which could be used for the next reaction without further purification.

References

[1] Patent: US6562811, 2003, B1

Methyl N-Boc-4-hydroxypiperidine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl N-Boc-4-hydroxypiperidine-3-carboxylate Suppliers

China 39 India 1 United Kingdom 1 United States 8 Global 49

Accela ChemBio Co.,Ltd.

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Accela ChemBio Inc.

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View Lastest Price from Methyl N-Boc-4-hydroxypiperidine-3-carboxylate manufacturers

Career Henan Chemical Co

Product: Methyl N-Boc-4-hydroxypiperidine-3-carboxylate 406212-51-9
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g； 1kg; 25kg
Release date: 2020-01-10

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406212-51-9