(1S,2R)-2-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid
- Product Name
- (1S,2R)-2-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid
- CAS No.
- 137170-89-9
- Chemical Name
- (1S,2R)-2-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid
- Synonyms
- (1S,2R)-2-(Boc-amino)cyclopentanecarboxylic Acid;N-Boc-(1S,2R)-2-Amino-1-cyclopentanecarboxylicacid;(1S,2R)-cis-2-(Boc-Amino)cyclopentanecarboxylic acid;(1S,2R)-2-(Boc-amino)cyclopentanecarboxylic Acid, ≥97%;(1S,2R)-2-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid;Cis-(1S,2R)-2-((tert-butoxycarbonyl)aMino)cyclopentanecarboxylic acid;(1S,2R)-2-{[(tert-butoxy)carbonyl]amino}cyclopentane-1-carboxylic acid;(1S,2R)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclopentanecarboxylic acid;Cyclopentanecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (1S,2R)-
- CBNumber
- CB92516593
- Molecular Formula
- C11H19NO4
- Formula Weight
- 229.27
- MOL File
- 137170-89-9.mol
(1S,2R)-2-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid Property
- Boiling point:
- 382.5±31.0 °C(Predicted)
- Density
- 1.15
- storage temp.
- 2-8°C
- pka
- 4.53±0.40(Predicted)
- form
- solid
- color
- White to off-white
- InChI
- InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-8-6-4-5-7(8)9(13)14/h7-8H,4-6H2,1-3H3,(H,12,15)(H,13,14)/t7-,8+/m0/s1
- InChIKey
- BUEPEVBYNBQNED-JGVFFNPUSA-N
- SMILES
- [C@H]1(C(O)=O)CCC[C@H]1NC(OC(C)(C)C)=O
Safety
- HazardClass
- IRRITANT
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
N-Bromosuccinimide Price
- Product number
- B603250
- Product name
- (1S,2R)-2-(Boc-amino)cyclopentanecarboxylicAcid
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- CS-0037061
- Product name
- (1S,2R)-2-((tert-Butoxycarbonyl)amino)cyclopentanecarboxylicacid
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FB154485
- Product name
- (1S,2R)-2-(Boc-amino)cyclopentanecarboxylicacid
- Packaging
- 1g
- Price
- $215
- Updated
- 2021/12/16
- Product number
- 4H58-1-JT
- Product name
- (1S,2R)-2-(tert-Butoxycarbonylamino)cyclopentanecarboxylic acid
- Packaging
- 250mg
- Price
- $248
- Updated
- 2021/12/16
- Product number
- FB154485
- Product name
- (1S,2R)-2-(Boc-amino)cyclopentanecarboxylicacid
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
(1S,2R)-2-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid Chemical Properties,Usage,Production
Synthesis
24424-99-5
64191-14-6
137170-89-9
Example 7: Synthesis of tert-butyl (1R,2S)-2-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)cyclopentylcarbamate Step 1: Preparation of (1S,2R)-2-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid At 25 °C, (1S,2R)-2-aminocyclopentanecarboxylic acid hydrochloride (515 mg, 3.11 mmol) was dissolved in water (5.00 mL) and stirred until completely dissolved. Subsequently, potassium hydroxide (349 mg, 6.22 mmol) was added. Then, a solution of di-tert-butyl dicarbonate (0.722 mL, 3.11 mmol) in dioxane (5 mL) was added dropwise to the reaction system. The reaction mixture was stirred continuously for 20 hours at room temperature. Upon completion of the reaction, the mixture was concentrated to remove the organic solvent. The remaining aqueous phase was extracted with chloroform three times (same amount each time). The chloroform extracts were combined, dried with anhydrous sodium sulfate, filtered and concentrated to afford (1S,2R)-2-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid (550 mg, 2.399 mmol, 77% yield) as a colorless viscous oil. The mass spectrum (ESI+) showed m/z = 230.30 ([M + H]+).
References
[1] Patent: WO2009/15166, 2009, A1. Location in patent: Page/Page column 76-77
(1S,2R)-2-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (1S,2R)-2-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid manufacturers
- Product
- (1S,2R)-2-(Boc-amino)cyclopentanecarboxylic acid 137170-89-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.5%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- (1S,2R)-2-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid 137170-89-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-07