4-Bromo-2-methyl-1-indanone
- Product Name
- 4-Bromo-2-methyl-1-indanone
- CAS No.
- 174702-59-1
- Chemical Name
- 4-Bromo-2-methyl-1-indanone
- Synonyms
- 4-Bromo-2-methyl-1-indanone;4-bromo-2-methyl-2,3-dihydro-1H--1-one;4-bromo-2-methyl-2,3-dihydroinden-1-one;4-broMo-2-Methyl-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one,4-bromo-2,3-dihydro-2-methyl-
- CBNumber
- CB92518476
- Molecular Formula
- C10H9BrO
- Formula Weight
- 225.08
- MOL File
- 174702-59-1.mol
4-Bromo-2-methyl-1-indanone Property
- Melting point:
- 27 °C
- Boiling point:
- 131-134℃ (2 Torr)
- Density
- 1.488±0.06 g/cm3 (20℃ 760 Torr)
- Flash point:
- 99.4±12.2℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Toluene
- form
- powder to lump to clear liquid
- color
- White or Colorless to Light yellow
Safety
- HS Code
- 2914.79.4000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B5096
- Product name
- 4-Bromo-2-methyl-1-indanone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- B5096
- Product name
- 4-Bromo-2-methyl-1-indanone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $157
- Updated
- 2025/07/31
- Product number
- B292740
- Product name
- 4-Bromo-2-methylindan-1-one
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B292740
- Product name
- 4-Bromo-2-methylindan-1-one
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B292740
- Product name
- 4-Bromo-2-methylindan-1-one
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
4-Bromo-2-methyl-1-indanone Chemical Properties,Usage,Production
Synthesis
869063-66-1
174702-59-1
General procedure for the synthesis of 4-bromo-2-methyl-2,3-dihydro-1H-inden-1-one from the compound (CAS: 869063-66-1): a mixture of starting acid (unspecified amount) and 160 mL of thionyl chloride (SOCl2) was stirred for 24 hours at room temperature. Subsequently, the excess thionyl chloride was removed by distillation. Under vigorous stirring, crude 3-(2-bromophenyl)-2-methylpropionyl chloride (dissolved in 270 mL of dichloromethane) was added drop-wise to 1350 mL of dichloromethane suspension containing 136 g (1.02 mol) of aluminum trichloride (AlCl3), keeping the reaction temperature at 0 °C for 1 hour. After that, the reaction mixture was refluxed for 3 h, cooled to room temperature and poured into 500 mL of ice water. The organic layer was separated and the aqueous layer was extracted with methyl tert-butyl ether (3 x 300 mL). The organic phases were combined and dried over potassium carbonate (K2CO3) and subsequently evaporated to dryness. Purification by fractional distillation afforded 4-bromo-2-methyl-1-indanone with a boiling point of 131-134 °C/2 mmHg in a yield of 125.5 g (75% yield) as a colorless solid. Elemental analysis (calculated value C10H9BrO): C, 53.36; H, 4.03. measured value: C, 53.19; H, 3.98. 1H NMR (300 MHz, CDCl3) δ: 7.76 (d, J = 7.6 Hz, 1H, 7-H), 7.71 (d, J = 7.6 Hz, 1H, 5-H), 7.28 (t, J = 7.6 Hz, 1H, 5-H), 7.28 (t, J = 7.6 Hz, 1H, 5-H). 7.6 Hz, 1H, 6-H), 3.36 (dd, J = 17.5 Hz, J = 7.6 Hz, 1H, 3-H), 2.70-2.82 (m, 1H, 2-H), 2.67 (dd, J = 17.5 Hz, J = 3.8 Hz, 1H, 3'-H), 1.34 (d, J = 7.3 Hz, 3H, 2-Me).13C NMR (75 MHz, CDCl3) δ: 208.3, 152.9, 138.2, 137.2, 129.0, 122.6, 122.0, 41.8, 35.7, 16.0.
References
[1] Patent: US2007/135597, 2007, A1
[2] Patent: WO2007/70040, 2007, A1. Location in patent: Page/Page column 104-105
[3] Patent: WO2007/70041, 2007, A1. Location in patent: Page/Page column 95-96
4-Bromo-2-methyl-1-indanone Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-Bromo-2-methyl-1-indanone manufacturers
- Product
- 4-Bromo-2-methyl-1-indanone 174702-59-1
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-20
- Product
- 4-Bromo-2-methyl-1-indanone 174702-59-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-19
- Product
- 4-Bromo-2-methyl-1-indanone 174702-59-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-13