ChemicalBook > CAS DataBase List > 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile

4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile

Product Name
4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile
CAS No.
1076225-27-8
Chemical Name
4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile
Synonyms
PF 998425;PF-0998425;4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile;Benzonitrile, 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl)-;rel-(-)-4-[(1R,2R)-2-Hydroxycyclohexyl]-2-(trifluoroMethyl)benzonitrile
CBNumber
CB92518779
Molecular Formula
C14H14F3NO
Formula Weight
269.26
MOL File
1076225-27-8.mol
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4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile Property

Boiling point:
365.2±42.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: ≥10mg/mL
form 
powder
pka
14.84±0.40(Predicted)
color 
white to off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0131
Product name
PF-998425
Purity
≥98% (HPLC)
Packaging
5mg
Price
$136
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0131
Product name
PF-998425
Purity
≥98% (HPLC)
Packaging
25mg
Price
$322.8
Updated
2024/03/01
Usbiological
Product number
019329
Product name
PF-998425
Packaging
10mg
Price
$475
Updated
2021/12/16
TRC
Product number
P294060
Product name
PF-998425
Packaging
100mg
Price
$1410
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010282
Product name
4-((1R,2R)-2-HYDROXYCYCLOHEXYL)-2-(TRIFLUOROMETHYL)BENZONITRILE
Purity
95.00%
Packaging
100MG
Price
$2055.9
Updated
2021/12/16
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4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile Chemical Properties,Usage,Production

Uses

PF-998425 is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia.

Biological Activity

PF-998425 is a novel, nonsteroidal androgen receptor antagonist.

in vivo

PF-998425 (Compound (-)-6a) is rapidly metabolized in rat liver microsomes (t1/2=4 min, CLint=350 (μL/min)/mg protein). In vivo clearance data in dogs are consistent with the high clearance predicted in vitro in rat. Following intravenous administration of PF-998425, mean systemic plasma clearance is 40 (mL/min)/kg. The mean apparent of volume of distribution at steady state is 6.5 L/kg, and the mean terminal phase half-life is 2.6 h[1].

4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile Suppliers

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View Lastest Price from 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile manufacturers

Dingwang Technology (Wuhan) Co., Ltd.
Product
PF-998425 1076225-27-8
Price
US $0.00/gram
Min. Order
1gram
Purity
99% HPLC
Supply Ability
20 tons
Release date
2022-12-08
Hebei Xinsheng New Material Technology Co., LTD.
Product
PF-998425 1076225-27-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20tons
Release date
2023-08-31
Anhui Ruihan Technology Co., Ltd
Product
4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile 1076225-27-8
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000t/year
Release date
2023-08-21

1076225-27-8, 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrileRelated Search:


  • 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile
  • PF 998425
  • rel-(-)-4-[(1R,2R)-2-Hydroxycyclohexyl]-2-(trifluoroMethyl)benzonitrile
  • PF-0998425
  • Benzonitrile, 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl)-
  • 1076225-27-8