COG 133

Product Name: COG 133
CAS No.: 514200-66-9
Chemical Name: COG 133
Synonyms: apoE(13;COG 133;apoE(133-149);COG-133; COG133;COG 133 TFA salt;Ac- LRVRLASHLRKLRKRLL-NH2;COG 133 trifluoroacetate salt;Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu- Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2;N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-Leucinamide;L-Leucinamide, N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-
CBNumber: CB92518926
Molecular Formula: C97H181N37O19
Formula Weight: 2169.71
MOL File: 514200-66-9.mol

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COG 133 Property

storage temp.: -20°C
solubility: H2O: >1mg/mL
form: lyophilized
color: white
Water Solubility: Soluble to 1 mg/ml in water

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C8624
Product name: COG 133 trifluoroacetate salt
Purity: ≥95% (HPLC)
Packaging: 1mg
Price: $259
Updated: 2024/03/01

Tocris

Product number: 3405
Product name: COG133
Packaging: 1
Price: $244
Updated: 2021/12/16

Usbiological

Product number: 255020
Product name: COG 133
Packaging: 1mg
Price: $495
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0004464
Product name: COG 133
Purity: 95.00%
Packaging: 5MG
Price: $495.85
Updated: 2021/12/16

ApexBio Technology

Product number: A1131
Product name: COG133
Packaging: 10mg
Price: $350
Updated: 2021/12/16

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COG 133 Chemical Properties,Usage,Production

Biological Activity

cog 133, (c97h181n37o19), a peptide with the sequence ac-leu-arg-val-arg-leu-ala-ser-his-leu-arg-lys-leu-arg-lys-arg-leu-leu-amide,mw= 2169.73.apolipoprotein e (apoe) is 299 amino acids long and transports lipoproteins(1), fat-soluble vitamins, and cholesterol into the lymph system and then into the blood. it is synthesized principally in the liver, but has also been found in other tissues such as the brain, kidneys, and spleen. in the nervous system, non-neuronal cell types, most notably astroglia and microglia, are the primary producers of apoe, while neurons preferentially express the receptors for apoe. there are seven currently identified mammalian receptors for apoe which belong to the evolutionarily conserved low density lipoprotein receptor gene family.apoe was initially recognized for its importance in lipoprotein metabolism and cardiovascular disease(2). defects in apoe result in familial dysbetalipoproteinemia aka type iii hyperlipoproteinemia (hlp iii), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron, vldl and ldl remnants[citation needed]. more recently, it has been studied for its role in several biological processes not directly related to lipoprotein transport, including alzheimer's disease (ad), immunoregulation, and cognition(3).figure1 the structures of apolipoprotein e (apoe) cog 133figure2 potential roles of apoe in neurons and alzheimer's disease

storage

Store at -20°C

References

1. Singh PP, Singh M, Mastana SS (2002). "Genetic variation of apolipoproteins in North Indians". Hum. Biol. 74 (5): 673–82.2. van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, BrennerMB. (2005). "Apolipoprotein-mediated pathways of lipid antigen presentation.". Nature 437 (7060): 906-10.3. Zhang HL, Wu J, Zhu J (2010). "The Role of Apolipoprotein E in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis". J. Biomed. Biotechnol. 2010: 357412.

COG 133 Preparation Products And Raw materials

Raw materials

Preparation Products

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COG 133 Suppliers

China 44 United Kingdom 1 United States 11 Global 56

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Creative Peptides

Tel
Email: info@creative-peptides.com
Country: United States
ProdList: 6083
Advantage: 56

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303 +86-17380623303
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4840
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Fax: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 6756
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3061
Advantage: 58

514200-66-9, COG 133Related Search:

CARBON MONOXIDE

COG 133 trifluoroacetate salt

N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-Leucinamide

Ac- LRVRLASHLRKLRKRLL-NH2

Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu- Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2

apoE(13

apoE(133-149)

COG 133

COG-133; COG133

L-Leucinamide, N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-

COG 133 TFA salt

514200-66-9

C97H181N37O19

Neuroscience