ChemicalBook > CAS DataBase List > BMS-599626

BMS-599626

Product Name: BMS-599626
CAS No.: 873837-23-1
Chemical Name: BMS-599626
Synonyms: CS-173;AC480 HCl;BMS-599626 HCl;BMS-599626 (AC480);BMS 599626 HCl (AC480);BMS-599626 (Hydrochloride);BMS-599626 hydrochloride (AC480;BMS-599626 Hydrochloride, 10 mM in DMSO;AC480;BMS-599626 HCL;BMS599626;BMS 599626;AC-480;(S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate hydrochloride
CBNumber: CB92519110
Molecular Formula: C27H28ClFN8O3
Formula Weight: 567.0144232
MOL File: 873837-23-1.mol

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BMS-599626 Property

storage temp.: Store at -20°C
solubility: ≥29.05 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 474078
Product name: BMS 599626 hydrochloride
Packaging: 100mg
Price: $2229
Updated: 2021/12/16

ChemScene

Product number: CS-0406
Product name: BMS-599626(Hydrochloride)
Purity: 99.87%
Packaging: 5mg
Price: $108
Updated: 2021/12/16

ApexBio Technology

Product number: A3252
Product name: BMS-599626Hydrochloride
Packaging: 5mg
Price: $132
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18844
Product name: BMS 599626 hydrochloride
Packaging: 10mg
Price: $175
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0013827
Product name: BMS-599626 HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $330
Updated: 2021/12/16

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BMS-599626 Chemical Properties,Usage,Production

Uses

BMS-599626 is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively.

in vivo

BMS-599626 Hydrochloride (60-240 mg/kg; p.o.; daily for 14 days) results in a dose-dependent inhibition of Sal2 tumor growth^[1].
BMS-599626 Hydrochloride treatment results in the inhibition of GEO xenograft tumor growth when given once daily for 14 days. In addition to efficacy in the Sal2, GEO, and KPL4 models, BMS-599626 has similar antitumor activity in other HER2 amplified xenograft models including the BT474 breast and N87 gastric tumors, as well as other HER1-overexpressing non-small-cell lung tumors (A549 and L2987)^[1].
BMS-599626 Hydrochloride given before and during irradiation improved the radioresponse of HN5 tumors in vivo^[2].

Animal Model:	Athymic female nude mice (nu/nu mice, Sal2 tumor model)^[1]
Dosage:	60, 120, 240 mg/kg
Administration:	Oral; daily for 14 days
Result:	Resulted in a dose-dependent inhibition of Sal2 tumor growth.

BMS-599626 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-599626 Suppliers

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873837-23-1, BMS-599626Related Search:

[4-[[1-[(3-Fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid (3S)-3-morpholinylmethyl ester hydrochloride

BMS-599626 (AC480)

BMS-599626 (Hydrochloride)

BMS-599626 HCl

AC480;BMS-599626 HCL;BMS599626;BMS 599626;AC-480

BMS-599626 hydrochloride (AC480

CS-173

AC480 HCl

(S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate hydrochloride

BMS-599626 Hydrochloride, 10 mM in DMSO

BMS 599626 HCl (AC480)

873837-23-1

C27H28ClFN8O3

C27H27FN8O3ClH

C27H27FN8O3HCl