ChemicalBook > CAS DataBase List > Aristolactam BIII

Aristolactam BIII

Product Name: Aristolactam BIII
CAS No.: 53948-10-0
Chemical Name: Aristolactam BIII
Synonyms: Aristolactam BIII;1,2,9-Trimethoxydibenz[cd,f]indol-4(5H)-one;1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one;Dibenz[cd,f]indol-4(5H)-one,1,2,9-trimethoxy-
CBNumber: CB92519574
Molecular Formula: C18H15NO4
Formula Weight: 309.32
MOL File: 53948-10-0.mol

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Aristolactam BIII Property

solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder
color: Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom

Product number: CFN98904
Product name: AristolactamBIII
Purity: ≥98%
Packaging: 5mg
Price: $593
Updated: 2021/12/16

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Aristolactam BIII Chemical Properties,Usage,Production

Description

Aristolactam BIII has moderate antitumor activity in selected cell lines. Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, HT-29 and A549 cell lines in vitro.

Uses

Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1].

target

PAFR

References

[1] Miri Choi, et al. Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine. 2021 Nov:92:153695. DOI:10.1016/j.phymed.2021.153695

Aristolactam BIII Preparation Products And Raw materials

Raw materials

Preparation Products

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53948-10-0, Aristolactam BIIIRelated Search:

aristolactam I

Aristolactam BIII

Dibenz[cd,f]indol-4(5H)-one,1,2,9-trimethoxy-

1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one

1,2,9-Trimethoxydibenz[cd,f]indol-4(5H)-one

53948-10-0