ChemicalBook > CAS DataBase List > 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide

2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide

Product Name
2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide
CAS No.
1083326-46-8
Chemical Name
2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide
Synonyms
1-(2-Amino-2-oxoethyl)-1H-pyrazole-4-boronic Acid Pinacol Ester;(1-(2-AMINO-2-OXOETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER;2-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetaMide;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetamide;2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]acetamide;1H-Pyrazole-1-acetaMide, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide;2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide 95%
CBNumber
CB92520150
Molecular Formula
C11H18BN3O3
Formula Weight
251.09
MOL File
1083326-46-8.mol
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2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide Property

Boiling point:
440.8±25.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
15?+-.0.40(Predicted)
Appearance
White to light yellow Solid
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Safety

HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
T302685
Product name
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetamide
Packaging
10g
Price
$1470
Updated
2021/12/16
Apolloscientific
Product number
OR360148
Product name
2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide
Purity
95%
Packaging
250mg
Price
$128
Updated
2021/12/16
Synthonix
Product number
T16462
Product name
2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide
Purity
97%
Packaging
1g
Price
$130
Updated
2021/12/16
SynQuest Laboratories
Product number
8H60-1-GA
Product name
2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide
Packaging
250mg
Price
$141
Updated
2021/12/16
Matrix Scientific
Product number
074535
Product name
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetamide
Purity
95+%
Packaging
500mg
Price
$250
Updated
2021/12/16
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2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide Chemical Properties,Usage,Production

Uses

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetamide, can be used in the preparation of pharmaceutical and biologically active compounds, including inhibitors and therapeutic agents.

Synthesis

269410-08-4

683-57-8

1083326-46-8

Step 1: 4-Pyrazoleboronic acid pinacol ester (200 mg, 1.03 mmol), 2-bromoacetamide (213 mg, 1.54 mmol) and cesium carbonate (1.27 g, 3.92 mmol) were dissolved in acetonitrile (5.0 mL), and the reaction was stirred for 3 hours at 90°C. After the reaction was completed, it was cooled to room temperature, the reaction mixture was diluted with water and extracted twice with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to afford pinacol ester of 1-acetamido-4-boronic acid (174 mg, 67% yield) as a white solid, which could be used in the next reaction without further purification.1H-NMR (400 MHz, CDCl3): δ 7.89 (s, 1H), 7.76 (s, 1H), 6.21 and 5.41 ( brs, 2H), 4.83 (s, 2H), 1.32 (s, 12H).

References

[1] Patent: WO2015/156601, 2015, A1. Location in patent: Page/Page column 51; 52
[2] Patent: WO2010/75270, 2010, A1. Location in patent: Page/Page column 170
[3] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0222; 0223
[4] Patent: EP3042907, 2016, A1. Location in patent: Paragraph 0286; 0287
[5] Patent: WO2008/154241, 2008, A1. Location in patent: Page/Page column 160

2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide Suppliers

China 61 Germany 1 India 1 United Kingdom 1 United States 6 Global 70
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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United States
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Adamas Reagent, Ltd.
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021-64823266
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Syntechem Co.,Ltd
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View Lastest Price from 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide 1083326-46-8
Price
US $1.00-1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-11-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide 1083326-46-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide 1083326-46-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

1083326-46-8, 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamideRelated Search:


  • 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetamide
  • 2-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetaMide
  • 1H-Pyrazole-1-acetaMide, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
  • (1-(2-AMINO-2-OXOETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER
  • 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]acetamide
  • 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide 95%
  • 1-(2-Amino-2-oxoethyl)-1H-pyrazole-4-boronic Acid Pinacol Ester
  • 1083326-46-8
  • C11H18BN3O3