N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

Product Name: N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide
CAS No.: 319460-94-1
Chemical Name: N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide
Synonyms: CS-671;AG 13958;AG-013958;AG13958 ≥95%;AG 13958;AG-13958;AG-13958 (AG-013958);AG-13958, 10 mM in DMSO;(E)-N-(2-Fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-py;Vascular endothelial growth factor receptor,AG 013958,AG 13958,inhibit,VEGFR,AG13958,AG-13958,Inhibitor,AG013958;(E)-N-(2-Fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide
CBNumber: CB92521102
Molecular Formula: C26H22FN7O
Formula Weight: 467.5
MOL File: 319460-94-1.mol

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N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide Property

Boiling point:: 647.8±55.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO: 5 mg/mL (10.70 mM; ultrasonic and warming and heat to 60°C)
form: Solid
pka: 12.13±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FA103515
Product name: AG 13958
Packaging: 1mg
Price: $240
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA103515
Product name: AG 13958
Packaging: 2mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0006794
Product name: AG-13958
Purity: 99.64%
Packaging: 5mg
Price: $425
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA103515
Product name: AG 13958
Packaging: 5mg
Price: $480
Updated: 2021/12/16

AK Scientific

Product number: SYN1004
Product name: AG13958
Packaging: 5mg
Price: $515
Updated: 2021/12/16

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N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide Chemical Properties,Usage,Production

Uses

AG-13958 (AG-013958), a potent VEGFR tyrosine kinase inhibitor, is used for treatment of choroidal neovascularization associated with age-related macular degeneration (AMD)[1].

in vivo

ST administration (Steroid injection) of AG-13958 suspension produces a depot of drug on the posterior surface of the sclera that provided sustained exposure to the choroid with little impact on peripheral tissues and no measurable systemic exposure^[1].

IC 50

VEGFR

References

[1] M.B. Kosa, et al. Ocular and Systemic Pharmacokinetics of AG-013958 With Sub-Tenon Administration To Cynomologus Monkeys. Investigative Ophthalmology & Visual Science May 2005, Vol.46, 5379.
[2] Solowiej J, et al. Substrate-specific conformational regulation of the receptor tyrosine kinase VEGFR2 catalytic domain. ACS Chem Biol. 2013 May 17;8(5):978-86. DOI:10.1021/cb400040z

N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide Suppliers

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319460-94-1, N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamideRelated Search:

FARNESENE ESTETROL CHOLESTEROL ESTERASE Ethylamine

N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

AG 13958

AG-013958

N-[2-Fluoro-5-({3-[(E)-2-(2-pyridinyl)vinyl]-1H-indazol-6-yl}amin o)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

(E)-N-(2-Fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-py

(E)-N-(2-Fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

AG13958 ≥95%

AG 13958;AG-13958

CS-671

1H-Pyrazole-5-carboxamide, N-[2-fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-

Vascular endothelial growth factor receptor,AG 013958,AG 13958,inhibit,VEGFR,AG13958,AG-13958,Inhibitor,AG013958

AG-13958, 10 mM in DMSO

AG-13958 (AG-013958)

319460-94-1

C26H22FN7O