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7-bromopyrrolo[1,2-f][1,2,4]triazin-4-amine

Product Name
7-bromopyrrolo[1,2-f][1,2,4]triazin-4-amine
CAS No.
937046-98-5
Chemical Name
7-bromopyrrolo[1,2-f][1,2,4]triazin-4-amine
Synonyms
7-BroMopyrrolo[2,1-f][1,2,4]triazin-4-aMine;7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine;100207;10G/3000 (T);Remdesivir-007;4-Amino-7-bromo-pyrrolo[2...;-bromopyrrolo[1,2-f][1,2,4]triazin-4-amine;7-bromopyrrolo[1,2-f][1,2,4]triazin-4-amine;7-Bromopyrrolo[1,2-f][1,2,4]triazin-44-amine;4-AMino-7-broMo-pyrrolo[2,1-f][1,2,4]triazine
CBNumber
CB92524820
Molecular Formula
C6H5BrN4
Formula Weight
213.03
MOL File
937046-98-5.mol
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7-bromopyrrolo[1,2-f][1,2,4]triazin-4-amine Property

Density 
2.09±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.82±0.30(Predicted)
Appearance
Off-white to gray Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B6237
Product name
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine
Purity
min. 95.0 %
Packaging
1G
Price
$56
Updated
2025/07/31
TCI Chemical
Product number
B6237
Product name
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine
Purity
min. 95.0 %
Packaging
5G
Price
$222
Updated
2025/07/31
ChemScene
Product number
CS-W000773
Product name
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine
Purity
99.47%
Packaging
1g
Price
$25
Updated
2021/12/16
Matrix Scientific
Product number
069273
Product name
4-Amino-7-bromo-pyrrolo[2,1-f][1,2,4]triazine
Purity
95+%
Packaging
25g
Price
$1510
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB63371
Product name
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine
Packaging
2g
Price
$431.6
Updated
2021/12/16
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7-bromopyrrolo[1,2-f][1,2,4]triazin-4-amine Chemical Properties,Usage,Production

Uses

7-bromopyrrolo[2,1-f][1,2,4]triazin-4-amine is used in preparation of N-Heterocyclic compounds for pharmaceutical use including as anticancer agents and PRMT5 inhibitors.

Synthesis

159326-68-8

937046-98-5

The general procedure for the synthesis of 4-amino-7-bromopyrrolo[2,1-f][1,2,4]triazines from 4-amino pyrrolo[2,1-f][1,2,4]triazines is as follows: a solution of anhydrous DMF (200 mL) containing 4-amino pyrrolo[2,1-f][1,2,4]triazines (21.0 g, 0.157 mol) was stirred and cooled to -20 °C, followed by the batch addition of 1,3-dibromo-5,5-dimethylglycolide (22.4 g, 0.078 mol), the addition process lasted 45 min. After completion of addition, stirring of the reaction mixture was continued for 45 min and the progress of the reaction was monitored by TLC (silica gel plate, GHLF, 5% CH3OH/CH2Cl2). Upon completion of the reaction, the reaction was quenched by the addition of saturated Na2SO3 solution (300 mL), the resulting suspension was stirred, and the solid product was collected by filtration. The filter cake was washed with water and dried by diafiltration. Subsequently, the dried solid was partitioned between ethyl acetate (1 L) and 5% sodium carbonate solution (1 L) to separate the organic and aqueous layers. The organic layer was washed with fresh 5% sodium carbonate solution and dried with magnesium sulfate. All organic phases were combined and filtered through a Magnesol pad and the filtrate was concentrated under vacuum to give the crude product 4-amino-7-bromopyrrolo[2,1-f][1,2,4]triazine (29.9 g, 90% yield). 21.5 g of the crude product was recrystallized in hot ethyl acetate (300 mL, 70 °C) to give a colorless solid (12.3 g) with about 2% of dibrominated byproducts. The structure of the product was confirmed by 1H-NMR (CD3OD) and mass spectrometry (LC/MS, +ESI): 1H-NMR δ 7.84 (s, 1H), 6.95 (d, 1H, J = 4.7 Hz), 6.71 (d, 1H, J = 4.7 Hz), 4.89 (s, 3H, -NH2 + H2O); MS m/z = 213.1 [M+H].

References

[1] Patent: WO2007/56170, 2007, A2. Location in patent: Page/Page column 74-75
[2] Patent: WO2007/64931, 2007, A2. Location in patent: Page/Page column 164
[3] Asian Journal of Chemistry, 2014, vol. 26, # 20, p. 7083 - 7084
[4] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 1, p. 133 - 137

7-bromopyrrolo[1,2-f][1,2,4]triazin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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7-bromopyrrolo[1,2-f][1,2,4]triazin-4-amine Suppliers

Americas 1 China 161 Europe 1 India 6 Japan 1 United Kingdom 2 United States 10 Global 182
Energy Chemical
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Shangchem Co., Ltd.
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Nanjing Habo Medical Technology Co., Ltd.
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View Lastest Price from 7-bromopyrrolo[1,2-f][1,2,4]triazin-4-amine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
7-bromopyrrolo[1,2-f][1,2,4]triazin-4-amine 937046-98-5
Price
US $0.00-0.00/KG
Min. Order
100g
Purity
98%HPLC
Supply Ability
100 KGS
Release date
2021-06-10
Hebei Yanxi Chemical Co., Ltd.
Product
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine 937046-98-5
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-12
Hebei Miaobian Biotechnology Co., Ltd
Product
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine 937046-98-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99.99
Supply Ability
10 Ton
Release date
2020-09-25

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