ethyl 1-methyl-1H-pyrazole-4-carboxylate
- Product Name
- ethyl 1-methyl-1H-pyrazole-4-carboxylate
- CAS No.
- 85290-80-8
- Chemical Name
- ethyl 1-methyl-1H-pyrazole-4-carboxylate
- Synonyms
- Ethyl 1-Methylpyrazole-4-...;Ethyl 1-methyl-1H-pyrazol-4-carboxylate;ethyl 1-methyl-1H-pyrazole-4-carboxylate;1-Methyl-1H-pyrazole-4-carboxylic acid ethyl ester;1H-Pyrazole-4-carboxylic acid, 1-ethyl-, methyl ester
- CBNumber
- CB92525382
- Molecular Formula
- C7H10N2O2
- Formula Weight
- 154.17
- MOL File
- 85290-80-8.mol
ethyl 1-methyl-1H-pyrazole-4-carboxylate Property
- Boiling point:
- 81-83 °C(Press: 0.2 Torr)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.11±0.10(Predicted)
- form
- low-melting solid
- color
- Pink
- InChI
- InChI=1S/C7H10N2O2/c1-3-11-7(10)6-4-8-9(2)5-6/h4-5H,3H2,1-2H3
- InChIKey
- GXKQVOXCQOQZED-UHFFFAOYSA-N
- SMILES
- N1(C)C=C(C(OCC)=O)C=N1
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E926650
- Product name
- Ethyl1-Methyl-1H-pyrazole-4-carboxylate
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H58-1-8W
- Product name
- Ethyl 1-methylpyrazole-4-carboxylate
- Packaging
- 250mg
- Price
- $44
- Updated
- 2021/12/16
- Product number
- 113170
- Product name
- Ethyl 1-methylpyrazole-4-carboxylate
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- J51178
- Product name
- Ethyl1-methyl-1H-pyrazole-4-carboxylate
- Packaging
- 5g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 4H58-1-8W
- Product name
- Ethyl 1-methylpyrazole-4-carboxylate
- Packaging
- 1g
- Price
- $128
- Updated
- 2021/12/16
ethyl 1-methyl-1H-pyrazole-4-carboxylate Chemical Properties,Usage,Production
Synthesis
37622-90-5
74-88-4
85290-80-8
General procedure for the synthesis of ethyl 1-methyl-1H-pyrazole-4-carboxylate from ethyl 4-pyrazolecarboxylate and iodomethane: Ethyl 1H-pyrazole-4-carboxylate (2.5 g, 17.9 mmol) and iodomethane (3.1 g, 21.5 mmol) were dissolved in N,N-dimethylformamide (DMF, 10 mL), followed by addition of potassium carbonate (K2CO3, 5.0 g, 35.8 mmol). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, water (50 mL) was added to the mixture and then extracted with ethyl acetate (EA, 50 mL × 2). The organic layers were combined, washed with saturated saline (40 mL), dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 8:1) to afford ethyl 1-methyl-1H-pyrazole-4-carboxylate (214 mg, yield: 85%) as a colorless oil.1H NMR (300 MHz, DMSO-d6): δ = 8.28 (s, 1H), 7.82 (s, 1H), 4.26 (q, J = 6.9 Hz, 2H), 3.87 (s, 3H), 1.25 (t, J = 6.9 Hz, 3H). Mass spectrum (MS): m/z 155.3 ([M + H]+).
References
[1] Patent: WO2018/89786, 2018, A1. Location in patent: Paragraph 00394
[2] Patent: WO2018/132372, 2018, A1. Location in patent: Paragraph 00375
[3] Patent: WO2017/42643, 2017, A1. Location in patent: Page/Page column 22
[4] Patent: WO2003/106459, 2003, A1. Location in patent: Page 115; 156
[5] Patent: WO2018/64119, 2018, A1. Location in patent: Paragraph 1326
ethyl 1-methyl-1H-pyrazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ethyl 1-methyl-1H-pyrazole-4-carboxylate manufacturers
- Product
- ethyl 1-methyl-1H-pyrazole-4-carboxylate 85290-80-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- ethyl 1-methyl-1H-pyrazole-4-carboxylate 85290-80-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- ethyl 1-methyl-1H-pyrazole-4-carboxylate 85290-80-8
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12