Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+%
- Product Name
- Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+%
- CAS No.
- 141761-82-2
- Chemical Name
- Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+%
- Synonyms
- Methyl 3-aMino-5-broMo-2-hydroxybenzoate;3-amino-5-bromo-2-hydroxybenzoate;Methyl-3-amino-2-hydroxy-5-bromobenzoate;Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+%;Methyl 3-amino-5-bromo-2-hydroxybenzenecarboxylate;3-Amino-5-bromo-2-hydroxy-benzoic acid methyl ester;Benzoic acid, 3-amino-5-bromo-2-hydroxy-, methyl ester;2-Amino-4-bromo-6-(methoxycarbonyl)phenol, 5-Bromo-2-hydroxy-3-(methoxycarbonyl)aniline;Methyl 3-amino-5-bromosalicylate, 2-Amino-4-bromo-6-(methoxycarbonyl)phenol, 5-Bromo-2-hydroxy-3-(methoxycarbonyl)aniline
- CBNumber
- CB92527902
- Molecular Formula
- C8H8BrNO3
- Formula Weight
- 246.06
- MOL File
- 141761-82-2.mol
Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+% Property
- Boiling point:
- 318.8±42.0 °C(Predicted)
- Density
- 1.706±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 8.99±0.23(Predicted)
- form
- air sensitive solid
- color
- Pale brown
Safety
- HazardClass
- IRRITANT
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M563123
- Product name
- Methyl3-Amino-5-bromo-2-hydroxybenzenecarboxylate
- Packaging
- 2.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4658-9-X5
- Product name
- Methyl 3-amino-5-bromo-2-hydroxybenzoate
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $287
- Updated
- 2021/12/16
- Product number
- 054242
- Product name
- Methyl 3-amino-5-bromo-2-hydroxybenzenecarboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $486
- Updated
- 2021/12/16
- Product number
- 4658-9-X5
- Product name
- Methyl 3-amino-5-bromo-2-hydroxybenzoate
- Purity
- 95.0%
- Packaging
- 250mg
- Price
- $106
- Updated
- 2021/12/16
- Product number
- HCH0369254
- Product name
- METHYL-3-AMINO-5-BROMO-2-HYDROXYBENZENECARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.93
- Updated
- 2021/12/16
Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+% Chemical Properties,Usage,Production
Synthesis
67-56-1
91983-31-2
141761-82-2
The general procedure for the synthesis of methyl 3-amino-5-bromo-2-hydroxybenzoate from methyl 5-bromo-2-hydroxy-3-nitrobenzoate (138.02 g, 0.5 mol) and methanol (1000 mL) was as follows: methyl 5-bromo-2-hydroxy-3-nitrobenzoate was mixed with methanol, followed by a one-time addition of activated iron powder (112 g, 2 mol). The reaction mixture was heated to a slightly refluxed state, saturated ammonium chloride solution (80 g, 1.5 mol) was slowly added dropwise and the reflux reaction was maintained for 3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction system was cooled to room temperature. Diatomaceous earth (200 g) was added to the cooled reaction mixture and filtration was carried out to obtain a black filtrate. The solid residue was washed well with hot methanol until no product was detected in the wash solution and the black solid was discarded. All the filtrates were combined and the solvent was removed by evaporation under reduced pressure. The crude product was purified by rapid chromatography on an 80-100 mesh silica gel column to afford methyl 3-amino-5-bromo-2-hydroxybenzoate (96-85 g) in 78% yield.
References
[1] Patent: CN107573336, 2018, A. Location in patent: Paragraph 0099; 0100; 0101; 0102
Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+% Preparation Products And Raw materials
Raw materials
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