ChemicalBook > CAS DataBase List > Methyl 5-chloro-6-methylpyrazine-2-carboxylate
Methyl 5-chloro-6-methylpyrazine-2-carboxylate
Pharmaceutical intermediate- Product Name
- Methyl 5-chloro-6-methylpyrazine-2-carboxylate
- CAS No.
- 77168-85-5
- Chemical Name
- Methyl 5-chloro-6-methylpyrazine-2-carboxylate
- Synonyms
- N-1H-BENZIMIDAZOL-4-YLFORMAMIDE;Methyl 5-chloro-6-methylpyrazine-2-carboxylate;1,4-Butanediamine,N1,N4-bis(7-chloro-5-quinolinyl)-;5-Chloro-6-methyl-2-pyrazinecarboxylic acid methyl ester;5-Chloro-6-methyl-pyrazine-2-carboxylic acid methyl ester;2-Pyrazinecarboxylic acid, 5-chloro-6-methyl-, methyl ester;Methyl 5-chloro-6-methylpyrazine-2-carboxylate ISO 9001：2015 REACH
- CBNumber
- CB92534595
- Molecular Formula
- C7H7ClN2O2
- Formula Weight
- 186.6
- MOL File
- 77168-85-5.mol
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Methyl 5-chloro-6-methylpyrazine-2-carboxylate Property
- Melting point:
- 40-43℃
- Boiling point:
- 260℃
- Density
- 1.314
- Flash point:
- 111℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder
- pka
- -3.86±0.10(Predicted)
- color
- Yellow
- InChI
- InChI=1S/C7H7ClN2O2/c1-4-6(8)9-3-5(10-4)7(11)12-2/h3H,1-2H3
- InChIKey
- GGNGFNQPYMKDDR-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC(C)=C(Cl)N=C1
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Safety
- HS Code
- 2933199090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
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N-Bromosuccinimide Price
TRC
- Product number
- M329985
- Product name
- Methyl5-Chloro-6-methylpyrazine-2-carboxylate
- Packaging
- 25mg
- Price
- $85
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC143858
- Product name
- 5-Chloro-6-methyl-2-pyrazinecarboxylic acid methyl ester
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC143858
- Product name
- 5-Chloro-6-methyl-2-pyrazinecarboxylic acid methyl ester
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
AK Scientific
- Product number
- J95233
- Product name
- Methyl5-chloro-6-methylpyrazine-2-carboxylate
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC143858
- Product name
- 5-Chloro-6-methyl-2-pyrazinecarboxylic acid methyl ester
- Packaging
- 2g
- Price
- $220
- Updated
- 2021/12/16
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Methyl 5-chloro-6-methylpyrazine-2-carboxylate Chemical Properties,Usage,Production
Pharmaceutical intermediate
The N-methyl-d-aspartate (NMDA) receptor is arguably an important signaling mechanism in the human brain and NMDA receptors play a critical role in regulating the strength of synapses, that is, in regulating synaptic plasticity. Methyl 5-chloro-6-methylpyrazine-2-carboxylate is the key materials to prepare the NMDA receptor.
Uses
Methyl 5-?Chloro-?6-?methylpyrazine-?2-?carboxylate is a reactant used in the synthesis of 4,5-dihydro-5-oxo-2-pyrazinecarboxylic acid 1-oxides.
Synthesis
77168-84-4
77168-85-5
The general procedure for the synthesis of methyl 5-chloro-6-methylpyrazine-2-carboxylate from methyl 6-methyl-5-oxo-4,5-dihydropyrazine-2-carboxylate was as follows: a solution of methyl 6-methyl-5-oxo-4,5-dihydropyrazine-2-carboxylate was added to POCl3 (20 mL) in DMF (20 mL). The reaction mixture was refluxed for 0.5 h and subsequently poured into ice water. The aqueous layer was extracted with CHCl3 and the organic phase was dried and concentrated with MgSO4. The residue was purified by silica gel column chromatography (eluent: CHCl3) to afford methyl 5-chloro-6-methylpyrazine-2-carboxylate (2.34 g, 52% yield); melting point 49-50 °C.
References
[1] Chemical and Pharmaceutical Bulletin, 1980, vol. 28, # 10, p. 3057 - 3063
[2] Patent: US5811428, 1998, A
Methyl 5-chloro-6-methylpyrazine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 5-chloro-6-methylpyrazine-2-carboxylate manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- 5-Chloro-6-methyl-2-pyrazinecarboxylic acid methyl ester 77168-85-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 10g
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2019-12-25
Career Henan Chemical Co
- Product
- Methyl 5-chloro-6-methylpyrazine-2-carboxylate 77168-85-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2020-01-13