1-methylcyclopropyl 4-nitrophenyl carbonate
- Product Name
- 1-methylcyclopropyl 4-nitrophenyl carbonate
- CAS No.
- 1046817-22-4
- Chemical Name
- 1-methylcyclopropyl 4-nitrophenyl carbonate
- Synonyms
- 4-Nitrophenyl 1-methylcyclopropyl carbonate;1-methylcyclopropyl 4-nitrophenyl carbonate;Carbonic acid, 1-methylcyclopropyl 4-nitrophenyl ester;1-methylcyclopropyl 4-nitrophenyl carbonate ISO 9001：2015 REACH
- CBNumber
- CB92535592
- Molecular Formula
- C11H11NO5
- Formula Weight
- 237.21
- MOL File
- 1046817-22-4.mol
1-methylcyclopropyl 4-nitrophenyl carbonate Property
- Melting point:
- 46-48℃
- Density
- 1.35±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 8049DN
- Product name
- 1-Methylcyclopropyl4-nitrophenylcarbonate
- Packaging
- 250mg
- Price
- $213
- Updated
- 2021/12/16
- Product number
- CD12184101
- Product name
- 1-Methylcyclopropyl(4-nitrophenyl)carbonate
- Purity
- 96%
- Packaging
- 1g
- Price
- $274
- Updated
- 2021/12/16
- Product number
- CM202217
- Product name
- 1-methylcyclopropyl(4-nitrophenyl)carbonate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $430
- Updated
- 2021/12/16
- Product number
- 61-10316
- Product name
- 1-Methylcyclopropyl(4-nitrophenyl)carbonate
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $432
- Updated
- 2021/12/16
- Product number
- 1046817224
- Product name
- 1-Methylcyclopropyl(4-nitrophenyl)carbonate
- Packaging
- 5g
- Price
- $926.44
- Updated
- 2021/12/16
1-methylcyclopropyl 4-nitrophenyl carbonate Chemical Properties,Usage,Production
Synthesis
29526-99-6
7693-46-1
1046817-22-4
1-Methylcyclopropanol (1300 mg, 17 mmol) and 4-nitrophenyl chloroformate (3842 mg, 19 mmol) were dissolved in 50 mL of dichloromethane under nitrogen protection and cooled to 0 °C. A solution of pyridine (1.7 mL) in 10 mL of dichloromethane was added dropwise to the above solution over 10 minutes. The reaction mixture was stirred at 0°C for 90 minutes. Upon completion of the reaction, the reaction was quenched with 50 mL of aqueous 0.1 M sulfuric acid. The organic phase was separated and washed sequentially with water, saturated sodium bicarbonate solution and saturated brine, then dried over anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was diluted with twice the volume of hexane to gradually precipitate a solid. The solid was collected by filtration and the filtrate was concentrated to dryness to give a colorless semi-solid product. The semi-solid product was recrystallized with 50 mL of hexane, filtered hot and the solid was washed with 2 x 10 mL of boiling hexane. The filtrate was concentrated to give the target compound 1-methylcyclopropoxy-4-nitrophenyl carbonate as a white solid with a melting point of 46-48 °C. The product was confirmed by 1H NMR (CDCl3): δ 0.72-0.82 (m, 2H), 1.02-1.15 (m, 2H), 1.66 (s, 3H), 7.38 (m, 2H), 8.27 (m, 2H). Elemental analysis (C11H11NO5) calculated values: C 55.70%, H 4.67%, N 5.90%; measured values: C 55.52%, H 4.52%, N 5.94%. Note: Triethylamine should not be used in this reaction because it will have a side reaction with chloroformate.
References
[1] Tetrahedron Letters, 2011, vol. 52, # 25, p. 3171 - 3174
[2] Patent: WO2010/6191, 2010, A1. Location in patent: Page/Page column 52-54
[3] Patent: WO2010/128414, 2010, A1. Location in patent: Page/Page column 72
[4] Patent: WO2010/140092, 2010, A1. Location in patent: Page/Page column 65
[5] Patent: WO2011/61679, 2011, A1. Location in patent: Page/Page column 53
1-methylcyclopropyl 4-nitrophenyl carbonate Preparation Products And Raw materials
Raw materials
Preparation Products
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