HX 531
- Product Name
- HX 531
- CAS No.
- 188844-34-0
- Chemical Name
- HX 531
- Synonyms
- HX 531;HX531 >=98% (HPLC);Retinoic acid receptors,inhibit,RAR/RXR,HX-531,Inhibitor,Retinoid X receptors,HX 531,HX531;4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid;4-(5,7,7,10,10-Pentamethyl-2-nitro-7,8,9,10-tetrahydro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid;Benzoic acid, 4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)-
- CBNumber
- CB92535673
- Molecular Formula
- C29H29N3O4
- Formula Weight
- 483.56
- MOL File
- 188844-34-0.mol
HX 531 Property
- Boiling point:
- 656.2±55.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF:15.0(Max Conc. mg/mL);31.02(Max Conc. mM)
DMF:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.29(Max Conc. mM)
DMSO:17.67(Max Conc. mg/mL);36.53(Max Conc. mM)
Ethanol:0.12(Max Conc. mg/mL);0.25(Max Conc. mM) - form
- A crystalline solid
- pka
- 3.70±0.10(Predicted)
- color
- Light yellow to orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML2170
- Product name
- HX531
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $93.95
- Updated
- 2025/07/31
- Product number
- SML2170
- Product name
- HX531
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $381
- Updated
- 2025/07/31
- Product number
- 20762
- Product name
- HX 531
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20762
- Product name
- HX 531
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 20762
- Product name
- HX 531
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
HX 531 Chemical Properties,Usage,Production
Uses
HX 531 is a novel RXR antagonist used to enhance transactivation of PPARγ and ST 13 preadipocyte differentiation. Helps in the reduction of triglyceride content in white adipose tissue, skeletal muscle and liver.
Biological Activity
HX-531 is a potent antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM. HX531 has been used in many studies of the various effects of retinoids and RXR activity in diseases such as diabetes, Parkinsonμs disease, often as a control for agonists such as Bexarotene. It was recently shown to promote white adipogenic differentiation and inhibit both basal and Bexarotene-induced brown adipogenic differentiation.
in vivo
HX531 (0.1% and 0.3% food additive, oral, for two weeks) prevents weight gain in mice on a high-fat diet and stops high blood sugar and high insulin levels induced by the high-fat diet, while increasing leptin levels[2].
HX531 (0.1% and 0.3% food additive, oral, for two weeks) blocks the enlargement of fat cells and alleviates insulin resistance[2].
HX531 (0.1% and 0.3% food additive, oral, for two weeks) directly antagonizes PPARγ/RXR, reducing molecules involved in fatty acid influx and fat formation in skeletal muscle, while increasing molecules involved in energy expenditure[2].
HX531 (0.1% and 0.3% food additive, oral, for 3-4 weeks) leads to a rebound in high blood sugar and insulin resistance associated with fat atrophy[2].
HX531 (10mg/kg, oral, daily, for 30 weeks) reduces body weight in rats, inhibits fat cell enlargement, and induces G0/G1 cell cycle arrest in fat cells[3].
| Animal Model: | KKAy mouse induced by HF or HC[2] |
| Dosage: | 0.1% and 0.3% food additive, 2 weeks |
| Administration: | Oral |
| Result: | Reduced the body weight of mice, fasting blood glucose, fasting plasma insulin, and insulin tolerance. Increased Rectal temperature, rosed oxygen consumption , and serum leptin levels went up. Lowered the expression of fatty acid translocase/CD36, increased the expression of β3-adrenergic receptors (β3-AR), and decreased free fatty acids (FFA), TNF-α, and resistin. Reduced the expression of lipogenic enzymes SREBP1 and SCD1, increased the expression of molecules involved in fatty acid burning like ACO, and molecules that dissipate energy like UCP2, lowered long-chain FA-CoA and triglyceride levels in muscle. |
| Animal Model: | PPARγ deficient mice [2] |
| Dosage: | 0.1% and 0.3% food additive, 3 and 4 weeks |
| Administration: | Oral |
| Result: | Prevented the reoccurrence of high blood sugar and insulin resistance associated with fatty atrophy. |
| Animal Model: | LETO and OLETF rats[3] |
| Dosage: | 10 mg/kg, daily, 30 weeks |
| Administration: | Oral |
| Result: | Suppressed weight gain and reduced the excretion of urinary albumin.Led to G0/G1 cell cycle arrest, inhibited adipocyte hypertrophy, and suppressed the proliferation activity of fat cells. |
storage
Store at +4°C
HX 531 Preparation Products And Raw materials
Raw materials
Preparation Products
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