2,4-di-chloropyrimidine 5-carboxylic acid amide
- Product Name
- 2,4-di-chloropyrimidine 5-carboxylic acid amide
- CAS No.
- 1240390-28-6
- Chemical Name
- 2,4-di-chloropyrimidine 5-carboxylic acid amide
- Synonyms
- 2.4-dichloropyrimidine-5-formamide;2,4-Dichloro-5-pyrimidinecarboxamide;2,4-dichloropyriMidine-5-carboxaMide;5-Pyrimidinecarboxamide, 2,4-dichloro-;5-aMinocarbonyl-2,4-dichloropyriMidine;2,4-Dichloropyrimidine-5-carboxamide 95%;2,4-di-chloropyrimidine 5-carboxylic acid amide;5-Carbamoyl-2,4-dichloropyrimidine, 5-Carbamoyl-2,4-dichloro-1,3-diazine
- CBNumber
- CB92536418
- Molecular Formula
- C5H3Cl2N3O
- Formula Weight
- 192
- MOL File
- 1240390-28-6.mol
2,4-di-chloropyrimidine 5-carboxylic acid amide Property
- Boiling point:
- 364℃
- Density
- 1.620
- Flash point:
- 174℃
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- solid
- pka
- 12.74±0.50(Predicted)
- Appearance
- White to yellow Solid
- InChI
- 1S/C5H3Cl2N3O/c6-3-2(4(8)11)1-9-5(7)10-3/h1H,(H2,8,11)
- InChIKey
- OACCNUGECQQVLB-UHFFFAOYSA-N
- SMILES
- NC(C1=CN=C(N=C1Cl)Cl)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- MNO000176
- Product name
- 2,4-Dichloropyrimidine-5-carboxamide
- Packaging
- 1g
- Price
- $379
- Updated
- 2026/04/30
- Product number
- B419310
- Product name
- 2,4-Dichloropyrimidine-5-carboxamide
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-W006700
- Product name
- 2,4-Dichloropyrimidine-5-carboxylicacidamide
- Purity
- 98.95%
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- X9578
- Product name
- 2,4-Dichloropyrimidine-5-carboxylicacidamide
- Packaging
- 1g
- Price
- $138
- Updated
- 2021/12/16
- Product number
- 4H48-5-18
- Product name
- 2,4-Dichloropyrimidine-5-carboxamide
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
2,4-di-chloropyrimidine 5-carboxylic acid amide Chemical Properties,Usage,Production
Synthesis
2972-52-3
1240390-28-6
5.1.32 Synthesis of 2,4-dichloropyrimidine-5-carboxamide (27): 2,4-dihydroxypyrimidine-5-carboxylic acid (25) (2.98 g, 19.1 mmol) was dissolved in POCl3 (7.10 mL, 76.4 mmol) followed by addition of PCl5 (13.1 g, 63.0 mmol). The reaction mixture was heated to reflux for 4.5 hours. After completion of the reaction, the mixture was cooled and concentrated under vacuum. Toluene (20 mL) was added to the concentrated residue and again concentrated under vacuum. The residue was dissolved in CH2Cl2 (20 mL) and filtered. The filtrate was concentrated under vacuum to afford 2,4-dichloropyrimidine-5-carbonyl chloride (26) as a yellow oil (4.38 g), which could be used in the next step without further purification. A solution of CH2Cl2 (5 mL) of 26 (4.38 g) was slowly added to a mixture of 28% aqueous NH3 (3 mL) and H2O (3 mL) at -10 °C and the reaction was stirred for 5 min keeping the temperature at -10 °C. At the end of the reaction, the organic solvent was removed under reduced pressure and the precipitate was collected by filtration to afford the target product 2,4-dichloropyrimidine-5-carboxamide (27) (3.13 g, 16.3 mmol, 85% yield) as a light yellow solid. The product was confirmed by 1H NMR (DMSO-d6) δ: 8.05 (1H, s), 8.17 (1H, s), 8.90 (1H, s) and MS (ESI) m/z: 192 (M + H)+.
References
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 13, p. 5609 - 5622
[2] Patent: US2011/130415, 2011, A1. Location in patent: Page/Page column 41
[3] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 55
[4] Patent: WO2010/97248, 2010, A1. Location in patent: Page/Page column 31-32
[5] Patent: US2012/22092, 2012, A1. Location in patent: Page/Page column 29
2,4-di-chloropyrimidine 5-carboxylic acid amide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-di-chloropyrimidine 5-carboxylic acid amide manufacturers
- Product
- 2,4-di-chloropyrimidine 5-carboxylic acid amide 1240390-28-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02