4-Amino-3,5-difluorobenzoic acid
- Product Name
- 4-Amino-3,5-difluorobenzoic acid
- CAS No.
- 500577-99-1
- Chemical Name
- 4-Amino-3,5-difluorobenzoic acid
- Synonyms
- NSC 135302;4-Amino-3,5-difluorobenzoic acid;Benzoic acid, 4-amino-3,5-difluoro-
- CBNumber
- CB92538997
- Molecular Formula
- C7H5F2NO2
- Formula Weight
- 173.12
- MOL File
- 500577-99-1.mol
4-Amino-3,5-difluorobenzoic acid Property
- Boiling point:
- 294.2±40.0 °C(Predicted)
- Density
- 1.536±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 4.18±0.10(Predicted)
- form
- powder
- color
- Faint to light orange
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A611198
- Product name
- 4-amino-3,5-difluorobenzoicacid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- X6997
- Product name
- 4-Amino-3,5-difluorobenzoicacid
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 4657-3-22
- Product name
- 4-Amino-3,5-difluorobenzoic acid
- Packaging
- 1g
- Price
- $149
- Updated
- 2021/12/16
- Product number
- HCH0320015
- Product name
- 4-AMINO-3,5-DIFLUOROBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.65
- Updated
- 2021/12/16
- Product number
- 4657-3-22
- Product name
- 4-Amino-3,5-difluorobenzoic acid
- Packaging
- 5G
- Price
- $592
- Updated
- 2021/12/16
4-Amino-3,5-difluorobenzoic acid Chemical Properties,Usage,Production
Uses
4-Amino-3,5-difluorobenzoic Acid can be used to treat gastric cancer.
Synthesis
110301-23-0
500577-99-1
The general procedure for the synthesis of 3,5-difluoro-4-aminobenzoic acid from 4-amino-3,5-difluorobenzonitrile was as follows: 4-amino-3,5-difluorobenzonitrile (354.3 mg, 2.3 mmol) was suspended in a 1 M aqueous sodium hydroxide solution (12 mL), and the resulting suspension was heated and reacted for 16 hours at 110 °C. After completion of the reaction, the mixture was cooled to room temperature and washed with ether. Subsequently, the aqueous phase was acidified to pH=2 with 10% KHSO4/Na2SO4 buffer and extracted with ethyl acetate (2×). The ethyl acetate extracts were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 3,5-difluoro-4-aminobenzoic acid (335 mg, 84% yield) as a yellow solid.1H NMR (300 MHz, chloroform-d) δ 7.66-7.58 (m, 2H).
References
[1] Journal of Materials Chemistry C, 2016, vol. 4, # 23, p. 5326 - 5333
[2] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 3, p. 250 - 255
[3] Patent: WO2018/136935, 2018, A1. Location in patent: Paragraph 00408
[4] Bioconjugate Chemistry, 2018, vol. 29, # 2, p. 324 - 334
[5] Journal of the American Chemical Society, 2012, vol. 134, # 51, p. 20597 - 20600
4-Amino-3,5-difluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Amino-3,5-difluorobenzoic acid manufacturers
- Product
- 4-Amino-3,5-difluorobenzoic acid 500577-99-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 50mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-08
- Product
- 4-Amino-3,5-difluorobenzoic acid 500577-99-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11