2,5-DiMethyl Celecoxib

ChemicalBook > CAS DataBase List > 2,5-DiMethyl Celecoxib

2,5-DiMethyl Celecoxib

Product Name: 2,5-DiMethyl Celecoxib
CAS No.: 457639-26-8
Chemical Name: 2,5-DiMethyl Celecoxib
Synonyms: Celecoxib-13;5-dimethyl Celecoxib;Celecoxib Impurity K;Celecoxib impurity T;Celecoxib Impurity 42;Celecoxib 2,5-Dimethyl;2,5-DiMethyl Celecoxib;2,5-DiMethyl-celecoxib DMC;2,5dimethyl Celecoxib,2,5 dimethyl Celecoxib;4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide
CBNumber: CB92543122
Molecular Formula: C18H16F3N3O2S
Formula Weight: 395.4
MOL File: 457639-26-8.mol

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2,5-DiMethyl Celecoxib Property

Melting point:: >138°C (dec.)
Boiling point:: 516.7±60.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: soluble20mg/mL, clear
pka: 9.67±0.10(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D7196
Product name: 2,5-Dimethyl-celecoxib
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $40
Updated: 2024/03/01

Sigma-Aldrich

Product number: 35342
Product name: 2,5-Dimethyl-celecoxib
Purity: VETRANAL , analytical standard
Packaging: 10mg
Price: $134
Updated: 2021/12/16

Cayman Chemical

Product number: 10008006
Product name: 2,5-dimethyl Celecoxib
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 10008006
Product name: 2,5-dimethyl Celecoxib
Packaging: 10mg
Price: $92
Updated: 2024/03/01

Sigma-Aldrich

Product number: D7196
Product name: 2,5-Dimethyl-celecoxib
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $407
Updated: 2024/03/01

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2,5-DiMethyl Celecoxib Chemical Properties,Usage,Production

Uses

2,5-Dimethyl-celecoxib has been used

To block the synthesis of prostaglandin E2 and to study effect of transforming growth factor-2 signaling towards cyclooxygenase-2 expression.
In an in vitro study to analyze its pro-oxidative capacities in metastatic melanoma/ breast cancer cells.
To study its interaction between silymarin on chemically induced osteoarthritis in rats.

Uses

A non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib.

Biochem/physiol Actions

Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.

storage

Room temperature

2,5-DiMethyl Celecoxib Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-DiMethyl Celecoxib Suppliers

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457639-26-8, 2,5-DiMethyl CelecoxibRelated Search:

4-[5-(2,5-DiMethylphenyl)-3-(trifluoroMethyl)-1H-pyrazol-1-yl]benzenesulfonaMide

2,5-DiMethyl-celecoxib DMC

2,5-Dimethylcelecoxib 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

2,5-DiMethyl Celecoxib

4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide

Celecoxib-13

Celecoxib Impurity 42

Celecoxib Impurity K

Celecoxib 2,5-Dimethyl

Benzenesulfonamide, 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-

5-dimethyl Celecoxib

Celecoxib impurity T

2,5dimethyl Celecoxib,2,5 dimethyl Celecoxib

457639-26-8

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