618094-85-2

Product Name: 618094-85-2
CAS No.: 618094-85-2
Chemical Name: 618094-85-2
Synonyms: Guan-fu base A hydrochloride;Guan-fu base A hydrochloride(1394-48-5 free base);Guan-fu base A hydrochloride(1394-48-5 free base), 10 mM in DMSO;Guanfu base A hydrochloride(1394485 free base),Guan fu base A hydrochloride(1394 48 5 free base)
CBNumber: CB92547913
Molecular Formula: ClH
Formula Weight: 36.46094
MOL File: 618094-85-2.mol

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618094-85-2 Property

InChI: InChI=1S/ClH/h1H
InChIKey: VEXZGXHMUGYJMC-UHFFFAOYSA-N
SMILES: [H]Cl

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Hazard and Precautionary Statements (GHS)

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618094-85-2 Chemical Properties,Usage,Production

Uses

Guanfu base A hydrochloride is an antiarrhythmic alkaloid with the ability to inhibit CYP2D6 enzyme activity. Guanfu base A hydrochloride can be used to inhibit arrhythmia-related diseases. Guanfu base A hydrochloride exhibits inhibitory effects on CYP2D6 in different species of organisms, including humans, monkeys, and dogs. The biological activity of Guanfu base A hydrochloride makes it have potential clinical application value[1].

References

[1] Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24. DOI:10.1124/dmd.114.060905
[2] Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms DOI:10.1124/dmd.114.060905
[3] Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. DOI:10.1097/FJC.0b013e318236e380

618094-85-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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618094-85-2 Suppliers

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618094-85-2, 618094-85-2Related Search:

Guan-fu base A hydrochloride

Guan-fu base A hydrochloride(1394-48-5 free base)

Guanfu base A hydrochloride(1394485 free base),Guan fu base A hydrochloride(1394 48 5 free base)

Guan-fu base A hydrochloride(1394-48-5 free base), 10 mM in DMSO

618094-85-2