618094-85-2
- Product Name
- 618094-85-2
- CAS No.
- 618094-85-2
- Chemical Name
- 618094-85-2
- Synonyms
- Guan-fu base A hydrochloride;Guan-fu base A hydrochloride(1394-48-5 free base);Guan-fu base A hydrochloride(1394-48-5 free base), 10 mM in DMSO;Guanfu base A hydrochloride(1394485 free base),Guan fu base A hydrochloride(1394 48 5 free base)
- CBNumber
- CB92547913
- Molecular Formula
- ClH
- Formula Weight
- 36.46094
- MOL File
- 618094-85-2.mol
618094-85-2 Property
- InChI
- InChI=1S/ClH/h1H
- InChIKey
- VEXZGXHMUGYJMC-UHFFFAOYSA-N
- SMILES
- [H]Cl
618094-85-2 Chemical Properties,Usage,Production
Uses
Guanfu base A hydrochloride is an antiarrhythmic alkaloid with the ability to inhibit CYP2D6 enzyme activity. Guanfu base A hydrochloride can be used to inhibit arrhythmia-related diseases. Guanfu base A hydrochloride exhibits inhibitory effects on CYP2D6 in different species of organisms, including humans, monkeys, and dogs. The biological activity of Guanfu base A hydrochloride makes it have potential clinical application value[1].
References
[1] Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24. DOI:10.1124/dmd.114.060905
[2] Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms DOI:10.1124/dmd.114.060905
[3] Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. DOI:10.1097/FJC.0b013e318236e380
618094-85-2 Preparation Products And Raw materials
Raw materials
Preparation Products
618094-85-2 Suppliers
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- Country
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