4-CHLORO-7-METHOXY-6-NITROQUINAZOLINE
- Product Name
- 4-CHLORO-7-METHOXY-6-NITROQUINAZOLINE
- CAS No.
- 55496-69-0
- Chemical Name
- 4-CHLORO-7-METHOXY-6-NITROQUINAZOLINE
- Synonyms
- 4-CHLORO-7-METHOXY-6-NITROQUINAZOLINE;7-methoxy-6-nitro-4-chloroquinazoline;4-chloro-6-nitro-7-methoxyquinazoline;Quinazoline, 4-chloro-7-methoxy-6-nitro-;New 4-CHLORO-7-METHOXY-6-NITROQUINAZOLINE
- CBNumber
- CB92548884
- Molecular Formula
- C9H6ClN3O3
- Formula Weight
- 239.62
- MOL File
- 55496-69-0.mol
4-CHLORO-7-METHOXY-6-NITROQUINAZOLINE Property
- Boiling point:
- 424.6±40.0 °C(Predicted)
- Density
- 1.518±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.53±0.70(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C9H6ClN3O3/c1-16-8-3-6-5(2-7(8)13(14)15)9(10)12-4-11-6/h2-4H,1H3
- InChIKey
- MJFJWOAETHEGGW-UHFFFAOYSA-N
- SMILES
- N1=C2C(C=C([N+]([O-])=O)C(OC)=C2)=C(Cl)N=C1
N-Bromosuccinimide Price
- Product number
- CS-B1283
- Product name
- 4-Chloro-7-methoxy-6-nitroquinazoline
- Purity
- 95.65%
- Packaging
- 250mg
- Price
- $101
- Updated
- 2021/12/16
- Product number
- CS-B1283
- Product name
- 4-Chloro-7-methoxy-6-nitroquinazoline
- Purity
- 95.65%
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 8100AB
- Product name
- 4-Chloro-7-methoxy-6-nitroquinazoline
- Packaging
- 1g
- Price
- $209
- Updated
- 2021/12/16
- Product number
- FC139416
- Product name
- 4-Chloro-7-methoxy-6-nitroquinazoline
- Packaging
- 500mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-B1283
- Product name
- 4-Chloro-7-methoxy-6-nitroquinazoline
- Purity
- 95.65%
- Packaging
- 5g
- Price
- $397
- Updated
- 2021/12/16
4-CHLORO-7-METHOXY-6-NITROQUINAZOLINE Chemical Properties,Usage,Production
Synthesis
1012057-47-4
55496-69-0
Step 22d. Synthesis of 4-chloro-7-methoxy-6-nitroquinazoline (Compound 0305): 7-methoxy-6-nitroquinazolin-4(3H)-one (Compound 0304, 3.8 g, 17.2 mmol) was suspended in phosphorus oxychloride (POCl3, 75 mL), and the reaction mixture was heated to reflux and maintained for 4 hours. Upon completion of the reaction, excess POCl3 was removed by distillation under reduced pressure. the residue was dissolved in a mixture of dichloromethane (50 mL) and aqueous sodium bicarbonate (NaHCO3) (50 mL), and the organic layer was separated and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to afford the target product 4-chloro-7-methoxy-6-nitroquinazoline (compound 0305, 3.4 g, 83% yield). The product was characterized by 1H NMR (DMSO-d6): δ 4.05 (s, 3H), 7.44 (s, 1H), 8.27 (s, 1H), 8.53 (s, 1H).
References
[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 267 - 276
[2] Patent: WO2008/33747, 2008, A2. Location in patent: Page/Page column 130
[3] Patent: US2009/76022, 2009, A1. Location in patent: Page/Page column 74-75
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 2000 - 2009
[5] Patent: US2009/111772, 2009, A1. Location in patent: Page/Page column 73
4-CHLORO-7-METHOXY-6-NITROQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLORO-7-METHOXY-6-NITROQUINAZOLINE manufacturers
- Product
- 4-Chloro-7-methoxy-6-nitroquinazoline 55496-69-0
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100000
- Release date
- 2023-09-11
- Product
- 4-CHLORO-7-METHOXY-6-NITROQUINAZOLINE 55496-69-0
- Price
- US $30.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2023-10-08
- Product
- 4-CHLORO-7-METHOXY-6-NITROQUINAZOLINE 55496-69-0
- Price
- US $35.00/KG
- Min. Order
- 100g
- Purity
- 98
- Supply Ability
- 10tons per month
- Release date
- 2021-09-27